So been reading around about
MTHFR and colitis and came across this study from 1999 about
the increased incidence of the polymorphisms in IBD patientsA total
of 17.5% of ulcerative colitis and 16.8% of
Crohn’s disease patients were homozygous
for the C677T variant compared with 7.3%
of controls. gut.bmj.com/content/45/3/389.full.pdf
I told my GI of my discovery that I have the polymorphism. He wasn't interested and did not suggest testing homocysteine, despite the fact that I have previously tested high for other clotting markers such as fibrinogen and d-dimer. He said there is no solid evidence as to how the polymorphism affects people with IBD.
What I find bizarre though is that it is known that people with IBD have increased incidence of blood clots, it is known that this polymorphism can pre-dispose to blood clots, yet I've never come across folate/B12 as a part of an IBD protocol ever unless the the patient is on methotrexate or another known folate blocker. The study thinks it should be " all patients with IBD are at risk of
folate and vitamin B12 deficiency, for the reasons enumerated above, it may be preferable to recommend that all patients with IBD shouldreceive daily folate and vitamin B 12 supplements to protect against the complications of hyperhomocysteinaemia."
As I said to the GI - in flare, my folate intake can go very low as cannot tolerate veg nor legumes and I got used to leaving them out even when not in a bad flare. I don't think this is unusual for an IBDer. Yet protocol when in flare if on extended best rest for IBDers in UK is Warfarin (which I am sure made my UC bleed worse the one time it was forced on me in hospital) - no one talks about
folate or B12 and B6.
I have started eating greens every day now, hoping my colon will tolerate this. I don't know if it will be enough. My strange symptoms of dizziness and anxiety type rushes have subsided since stopping the B-complex with folic acid. However, that complex did help as well as harm I believe as I have had less viral infections and a better menstrual cycle while on it. Thinking about
taking activated folate, activated B12 and b6 (P5P) but wondering if I could just do it with food - interesting that spinach with sunflower seeds, which many on here find helpful, would be an excellent source of folate and b6.
Anyone else apart from PK found out about
their MTHFR status?