A really good page about MTHFR polymorphisms and how they might effect UC

Dont agree with every single part of it.. Im not positive about the whole copper conclusion.. but I think the explanation of methylation is understandable.

symptomsofulcerativecolitis.org/causes-of-ulcerative-colitis-symptoms/genetics-and-ulcerative-colitis/lesson-on-methylation/

Post Edited (PathogenKiller) : 5/23/2013 8:27:37 PM (GMT-6)

I bet you have one with how you react to everything! You should try it. I think the butryate and the methylation support have been my biggest healers. Think about L-5-Methyltetrahydrofolate too.

also, thought about you when my doc said berberine + butyrate is a yeast killing powerhouse.. butyrate does all kinds of good stuff for the methylation cycle too.

We need a b-12 + L-Mthf trial!

Am I the only one who thinks of a dirty phrase each times I've seen the name of that gene? MTHFR?

Okay, so I felt like CRAP the first week on B12/ l-MethylTetrahydrofolate. I was saying lotsa that word that looks like MTHFR. I took tons of epsom salt baths to help get past that and was dutiful about my binder (Psyllium/apple pectin) It really was bad. My head hurt. I broke out horribly on my face too. Ive never had acne. Im still dealing with the last bit of the cysts that came up on my jaw line still, 2 months later! I also smelled so bad. My stomach was a little wonky, but the body and head pain was the worst of it. I smelled in the bath, there was no washing it off completely. I also started my period early and had it for 2+ weeks lightly. Another cleansing attempt by my body. My reaction sucked but it just spoke to how much I needed to start fixing my methylation. I have one copy of both MTHFR A1298C and C667T. so my pathways are particularly blocked My doctor had me add 5000mcg B12 and ramp up L-Methyltetrahydrofolate by 1000mcg a week till I got to 5000mcg. Now, Ive upped it on my own to 7000mcg because that is where I feel best. This is a controversial level of supplementation but I notice a HUGE difference in my memory and brain function on this dose.

So for me it was a detox reaction, I think triphala really helped me during that period too. And lots and lots of water. Ive since added additional methylation cycle supports and they have been very positive, giving me energy. Phosphytidyl serine, TMG, L-Carnitine and Co-Q10, and BH4

BUT that could also indicate you have a problem somewhere else in the cycle.. Like at COMT or CBS. Or some of the other stuff you were taking then.. it looks from the multiple threads you were spinning lots of things. for me, I make changes 1 at a time, slowly.

Old Mike, do you react to sulfur or sulfites Do you have any mercury fillings? are your homocysteine levels above 8?

High end is worthy of paying attention to. Doc says mine is too high at 10.8. I'd be curious to hear if you try it again and only ad b12 and l-mthf. use hydrocobalamin while you get it going.. Add Nac after a few weeks then later down the road you could use methylcobalamin after any residual mercury clears

I know you have a lot of different experiments but I hope you revisit this one!

deltaforce, glad you are getting tested. Will be curious.

triphala is a bunch of great things all rolled into one. It can be laxative, it can also be calming. It detoxes.. it is one of the few herbs we have evidence on that break up biofilms (this is huge for people with gut issues) It is very high in vitamin C.. it is antimicrobial. It is mucolytic.. There is a reason it is beloved in aryuveda. It could cause some clearing d.. maybe, if you ramped up slowly just taking 1 before each meal, unless you are allergic to a part of it, you should not have that experience. If you take many at night, like I do.. yes.. it could cause D. If you are constipated and take alot, yes you are likely to have D.. just dont take as much. This is not some scary herb that is going to send your digestive system into a tailspin. Start slow, be measured.

Thanks for posting. I am going to read it all slowly when less sleepy.

This copper thing fascinates me, probably posted elsewhere that when I read this piece about the "copper personality"VIEW IMAGE, so much sounded like it could be me
..and when I read the description of Wilson's disease (inability to metabolise copper), it sounded exactly what my Mum went through with her Multiple Sclerosis (minus the liver cirrhosis).

Plan on getting copper levels tested once my ESR goes back down in range and I can afford it. I had serum copper and free copper tested when I was in flare and they were really high, out of range. No GI would be interested in that though. Not sure if it worth paying for the MTFHR mutation blood tests.

Meanwhile, the thought that copper is massively high in chocolate is helping me stay off the stuff....

Have been thinking about zinc but when I had that blood test the zinc levels were also out of range (over). Am figuring that probably getting enough zinc from eating small amounts of organic meat most days. When I test the copper will do zinc again. Don't want to drain my body of copper (which zinc will do) if it does need it. There are some case studies I found online of people who overdid zinc and ended up with copper deficiency...but certainly very interested if improving copper metabolism might bring up my iron levels that have never been above borderline, even when definitely no bleeding from the colon.

I'm so not good at interpreting raw data. You should run it through genetic genie to make sure. Please please please cross check what I'm saying.

I think rs1801133 1 11778965 means you have Mthfr 677cc the normal, wild type fully functioning genetics

1801131 = 1298CC meaning homozygous for the polymorphism
mthfr.net/mthfr-a1298c-mutation-some-information-on-a1298c-mthfr-mutations/2011/11/30/

rs2274976 1 11773514 CC = mthfr 1793 aa.. Which I think is good.. I'm not as familiar with this snp.

Your blood levels mean nothing from my understanding.

Okay, so apparently I do have a homozygous A1298C MTHFR mutation.

King of the Toilet said...
Hello Pathogenkiller,

According to this MTHFR gene is identified by these three SNPs: rs1801133, rs1801131 and rs2274976.

I've been tested by 23andme and found these. How can I interpret these results?

rs1801133 1 11778965 GG
rs1801131 1 11777063 GG
rs2274976 1 11773514 CC

I should also note that my blood tests show normal values for folic acid/B12. Does this mean anything?

Submit your results on http://geneticgenie.org/ and see the results. Its the best way that I am aware of for novice to get the conclusions.

BTW, your handle made me ROFL :))

My doc put me on sodium butyrate for colitis as well as ammonia caused by pathogens and my mthfr mutations. I'm heterozygous for 1298 and 677. It is one of the most potent detoxifiers of ammonia..

Be careful dosing yucca if u go that route... it can be hard on the stomach.

Yes, you need l methyl, start at 1000 mcg , ramping up. Deplin is 10 mg, so, basically it's a process to see where you feel good at. Try adding 1000mcg per week to 5000 total and see how you feel. If you have depression or anxiety, this is gonna help you a ton! you could also supplement b4, maybe. What else did genetic genie say about your other genes, they all work together.

For the colitis and the ammonia caused by pathogens. I don't take any extra. Got enough ;)


I think all Comt must be addressed first. ...I'll post more this weekend for you...