The thing Im still unsure of is if 23andme tests for both A1298C and C677T I know they test for others, but from what I understand these are the two most linked polymorphisms.
Alba29, folic acid is a nonuseable form of B9 for people who have MTHFR polymorphisms. Depending on how many errant genes you have, depends on just how unusable. I am also compound heterozygous, one bad copy of each of those polymorphisms. That means I my methylation cycle could be anywhere from 30-70% impeded. If you only have one bad copy, yours may only be 30% impeded. From what I understand the double wammy is having both. Ive heard that you cant be homozygous for both of those genes and live.
I cannot use folic acid in food. Instead it just floats around in my body, imparing the methylation cycle. It shows great on testing, but none of the supplemented folic acid in my blood is useable. Because it isnt useable there is a break in my methylation cycle that prevents my body from doing all the things it needs to do to have good gene expression, as well as to detoxify.
So, my body was basically a toxic waste dump with a doggie door being the only way out.
By supplementing B-12 (if you have mercury fillings or a history of mercury fillings, you may consider hydroxocobalamin or adenosylcobalamin- there is some concern and very very little actual studies about
methylcobalamin being able to combine with mercury in these people, creating methyl mercury. The studies I have found showing this reaction can even occur, seem to include very high doses, and some type of perfect storm kind of conditions.. BUT, its best to be safe then sorry.) and L-methyltetrahydrofolate... You are able to provide your body with the supplies it needs to build a better and bigger door and get all the toxins that have been poisoning you and keeping your autoimmune system on edge.
Maybe your body will be better able to process enriched products later, dunno.
There are additional polymorphisms that can also be effecting folks with auto immune disease. Another one I think is important is CBS mutations. They regulate how much glutathione you make.. which are the trucks that take the waste out of the dump and all the workers helping with that process. If you react to sulfur or sulfites, this is one to explore more.
Here is a link to a page I thought had good information for UC sufferers. I like the descript
ion of MTHFR and methylation but havent figured out what to think about
the contention that copper is behind UC.www.healingwell.com/community/default.aspx?f=38&m=2739777
I think lots of heavy metals get involved in things when your detox pathways are closed and you have chronic disease and likely bacteria and viruses using metals to build biofilms.
Current: No Dairy, Sugar, Wheat.. Olive leaf (20% Oleuoropein), NA-Cysteine, Triphalia, METHYLATION polymorphism support, sodium butyrate, anantamul, neem, Blis K12, Probiotics, Proteolytic enzymes
My story www.healingwell.com/community/default.aspx?f=38&m=2644147