Congratulations you are on the right track. I think the key is keep the levels of the "good" bacteria high enough for long enough to deal with any reoccurrence of the inflamation-causing bacteria. This is why it might need to be continued over a longer period of time like that. However I think treating the inflamation and slowing diarrhea can also help retain the enemas more effectively and help the "new" bacteria colonize more rapidly.
@killcolitis good question. Why do I attribute this to FTs and not anti-depressants? It is true my big break where the symptoms suddenly stopped did happen about
a day after reducing the Prednisone dosage from 30 to 20 as the start of a rapid taper off Prednisone, I also started to take Apriso again, as well as mesalamine suppositories, Bupropion (an NDRI) and Silenor which is a low dose of the off-patent tri-cyclic anti-depressant Doxepin (6 mg) now marketed for sleep maintenance. However with the exception of Doxepin I had taken everything else in the past without any breakthroughs. I am no longer taking any of the drugs and as far as I know the other cases of remission from Bupropion ended when they stopped taking it. It makes sense to me that altering the gut flora is what has produced a sustainable absence of symptoms since almost all other treatments need to be continued to maintain remission.
@hateuc after my gut settled down from FMT treatments I discovered that many foods which previously appeared to cause problems no longer caused problems for me. I think maybe when the lining of the intestine heals and the bacteria change that food intolerances or allergies can also change.
@Probiotic For testing, it does seem like this is a bit of a wildcard. If the person has consistently had healthy bowel movements for years, will their stool introduce any harmful pathogens that cause illness in another person? It's possible, maybe in the would-be donor potentially bacteria is kept in check by the other existing strains of bacteria and an otherwise calm digestive tract which is free of inflammation. It seems to me that could explain why some people have had a flare in their symptoms before getting better if they continued through the flare until it got better again.
I think it is also possible that the recipient's immune system has to "reset" itself to adapt to the new mix of bacteria. Basically recalibrating how it determines friend or foe. When organs are transplanted immune suppressing are used to manage the transition so that the person's body does not reject it and for blood transfusions the same type of blood is used so that the body doesn't try to fight it. Maybe this is why taking immune suppressing drugs during fecal transplants is important.
As for bacteria working it's way up the colon, I had pan Colitis all the way up through my colon and based on all that I have read about
UC, it usually starts in the lower sigmoid colon or rectum and spreads up through the colon. For me I guess the bacteria must have eventually made its way up there perhaps through a combination of slowing diarrhea using the anti-spasmodic (anti-depressant) drugs and continued FTs. You can also get it deeper in there using a colonosope, higher volume enemas and by moving your body to help the mixture flow up into the colon. And there is always the possibility of putting poop in an enterically-coated capsule.
Post Edited By Moderator (Michelejc) : 6/10/2013 11:31:21 AM (GMT-6)