Posted 8/2/2013 11:42 AM (GMT -6)
Munchkindd, I recommend you give "Balancing the Risks and benefits of Treatment for Inflammatory Bowel Disease" by the Crohn's and Colitis Foundation of America a read:
Slide 21: Main Side Effects of Anti-TNF Treatment
So going to malignancy first. And, again, I think these are the most concerning to both patients and providers and families when you think about starting a medication that might actually cause cancer, which is a scary thing to think about. But to remind you of the baseline risk, meaning those people walking around on no medications at all of non-Hodgkin’s lymphomas, about 2 people out of 10,000 (or 0.02%). On the immunomodulators, it’s about 4 people out of 10,000 (or 0.04%), as I mentioned a few slides ago. If you’re using anti-TNF medications along with immunomodulators, although the risk is a little bit higher, it’s still about 6 people out of 10,000 (or 0.06%). So, again, the new story would be a triple risk from 2 to 6, but still a very, very small number.
Slide 37: Putting Risk in Perspective
We also need to put this in perspective, that just being alive and walking around the planet, we have risks of bad things from happening to us. Although very few of us have either been struck by lightning or know somebody who’s been struck by lightning, it happens. But look at these numbers for other things that we do every day. The chance of dying over your lifetime from a biking accident is 1 per 5,000; drowning, 1 per 1,000. And believe it or not, in the US, the chance of dying in a car accident is about 1 out of 260. The chance of dying from cancer is 1 out of 8, and the chance of dying for heart disease is 1 out of 5. Now, remember this isn’t patients with Crohn’s disease. This is people in general. So when we’re talking about side effects of medications on the order of 1 per 10,000, 6 per 10,000, we’re taking extremely small risks to help make you feel so much better and get the quality of life back to where it should be.