@indycat - Don't know if there are long term side effects. After 5 months I've not noticed any. I have read that nicotine can increase blood pressure, however mine is fine (possibly due to exercise and that I've been able to keep my bodyfat ratio out of the danger zone). I'm somewhat worried about
the possibility of nicotine addiction, but so far I don't have any compulsion to use patches other than paranoia that the UC might return.
@rbatalo - I've never smoked, and don't intend to do so. There was published evidence that this works for nonsmokers so I tried the patches (see earlier posts for more details).
@wodin - The nonsmoking patients in the published reports apparently had a high rate of noncompliance due to the annoyances of the patches. This perhaps made the evidence for maintenance less strong, and as you indicated, perhaps few biomedical researchers would want to face the fire by claiming nicotine could be beneficial, for two reasons: 1) smoking is bad for you, and no one wants to encourage it 2) nicotine cannot be patented and sold as a UC remedy. Another thing is that clinical trials cost money the longer they run, and the trials were preset to run for a relatively short length of time. Planning a longer trial would be very expensive and it is unlikely that grant funds could be obtained for such a long trial, particularly if a number of patients drop out due to noncompliance.
My current opinion: I don't believe in miracle cures. I expect that nicotine has its place in inducing remission, and may even be useful during maintenance, but eventually one has to lower the dose so your receptors don't adapt. The drug probably works by triggering nicotine receptors, and they are likely to adjust their expression levels by feedback mechanisms to achieve a new baseline, rendering the drug ineffective over time.
Post Edited (IcRed) : 1/9/2014 10:36:06 PM (GMT-7)