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In vitro batch cultures of gut microbiota from healthy and ulcerative colitis (UC) subjects suggest

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Ulcerative Colitis
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Posted 8/15/2013 5:35 AM (GMT -6)
FYI:

Peptones are the partial hydrolysis products from acid digestion of protein.

Old Mike

http://www.ncbi.nlm.nih.gov/pubmed/23941288

Post Edited (Old Mike) : 8/15/2013 5:39:57 AM (GMT-6)

Posted 8/15/2013 6:11 AM (GMT -6)
0-ajpgi.physiology.org.library.pcc.edu/content/292/1/G429#sec-16

oddly I was reading this this morning. Ties into to Short Chain Fatty Acid aspect and butyrate
Posted 8/15/2013 6:15 AM (GMT -6)
How does this translate into a treatment plan? This is the kind of stuff they should be studying a lot more.
Posted 8/15/2013 6:26 AM (GMT -6)
Also I came across that as I was/still am reading about the effects of constant low dose exposure to endocrine disrupting hormones. e360.yale.edu/feature/scientists_warn_of_low_dose_risk_of_endocrine_blocking_chemical_exposure/2507/ - there's a gazillion other actual paper on them.

I really think that very long term low dose exposure to these "synthetic hormone" chemicals in pesticides and other things, for some people and for some unknown reason are screwing with our system and hormones which is totally changing the way our bodies work and respond to various foods and bacteria. Like Neonicotinoids, exposure to tobacco smoke early on in life, and many other insecticides etc etc...
Posted 8/15/2013 6:47 AM (GMT -6)
Interesting find Mark.  Yes we are awash in a sea of toxins.

Better living through chemistry, NOT.


Gary:The hydrogen sulfide/SRB theory of UC has been around since at least 2000 or way before.
The milk fat findings also enhance SRB growth,due to taurine conjugated bile.
When eating protein or excess protein some escapes digestion in the upper gut and gets to the colon,
where protein fermentation by bacteria takes place in the distal colon.,also I suspect excess proteolytic enzymes to be generated and or not deactivated.
Remember UC starts distally.
Starch or resistant starch also escapes to the colon,this generates SCFA's which feed the colon cells, also
feeds different bacteria.
Bottom line eat less protein and more starch/resistant starch.
Does it work,perhaps to prevent UC.
Will it put you into remission,perhaps on some people,once immune cascade starts difficult to fix.
Sort of flies in the face of Paleo diet,or is it cooking methods.
Extra Bottom Line: Theory sounds good,but I don't have a clue,the above just one more factoid to this mess.
Old Mike

Then of course, and we always seem to have an of course.

http://www.ncbi.nlm.nih.gov/pubmed/23940796

Post Edited (Old Mike) : 8/15/2013 7:23:50 AM (GMT-6)

Posted 8/15/2013 10:46 AM (GMT -6)
A lot of this makes sense except for one thing, in my case. Whenever I eat meals that are higher in protein my UC seems to be better. A nice juicy steak gives me a good day. Most people would say that my diet leans toward being starchy, although I can't say it is the resistant variety. I'm giving some thought to eating some navy beans every day for a while and see what happens. How on earth do you eat navy beans, by themselves, or as part of something? For a few days I took Zymactive, which is a variety of proteolytic enzymes and I immediately got much worse. Had to discontinue them almost right away. Does that mean anything? I was taking them at the time because I felt that my UC was being caused by the Epstein Barr Virus and I found research showing that these enzymes helped fight EBV. I now believe my UC was caused by broad spectrum antibiotics which I was given to combat what later turned out to be Mono, which they didn't realize in the beginning.
Posted 8/15/2013 1:36 PM (GMT -6)
Gary: As I mentioned Paleo which could be a high meat diet seems to help some people,which
seems to not make sense if high protein is the problem with UC,or perhaps it is enough to eat organic and no processed foods with chemicals and everything stripped out.
As you found out extra proteolytic enzymes do not seem to be good for UC,this is part of the puzzle/solution. I have a big thread or threads on protease in the colon.
Old Mike
Posted 8/25/2013 11:24 AM (GMT -6)
Hey OM

I landed in a bit of a flare a few weeks ago. I did a few things and now see quite a substantial difference.

First: I made a dosage change on the Amino Acid treatment - this seemed to have helped. Second, at the same time I started to take one tablespoon of psyllium seeds (I run them through the coffee grinder first a few times but they don't reduce to power to much) daily and eat either navy beans with every meal and/or navy bean pasta. Also, I seem to digest the psyllium seeds quite well actually. I just down the tablespoon full in a small amount of water.

Took a few days but the combo of both seems to have brought back very large bowel movements, ability to go out and such without concern and some highly solid, formed stool as of today.

Like a lot of poop... haha... but it sure feels good...
Posted 8/25/2013 6:05 PM (GMT -6)
Good for you Mark:
I am awash in good Canadian VO right now,so no real comment.
I am wokig on dysbiois and nitrates/iNOS. We wqill see.
Old Mike
Posted 8/25/2013 8:54 PM (GMT -6)
Haha.. the original distillery for that is (or was up until 10 or 15 years ago) about 20 min away from me...

It's good stuff.

Our town was built from that place in the first big industrial boom... then blackberry (RIM) in the tech boom... and now, well, who knows. crazy how fast times change.
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