Mark: Its funny since earlier on the stool microbiome I mentioned we don't have the complete picture
of what is going on just from stool analysis, and that we need mucosa analysis,
then this pops up and gives us some idea. Even though it is a small sample size,perhaps enough to generalize.
Anyhow I find it real interesting that the healthy controls had zero intracellular bacteria.
We might have defective immunity,defective autophagy,barrier defects, or all at the same time.
But as we learn fro the oxygen hypothesis,all these facultative anaerobic e.coli should not be there in the first place in high numbers.
As my cousin Vinny would say, I think I am going with option B, barrier defect. which then leads to inflammation
and then, extra facultative anaerobes/dysbiosis, then perhaps defective immunity.
Why do I come to this guess at least for UC.
FT can put some into remission,it would seem it corrects somehow the dysbiosis,although
it may correct barrier defects by supplying bacteria that deactivates protease,might even fix immune
Antibiotics can trigger UC,they kill off good bacteria and I believe can disrupt barrier function.
After quitting smoking in 1977,this gave me a non suppressed immune system,then bam UC 1980.
Did my immune system suddenly go defective,killing off good bacteria and creating inflammation.
If it did then very strange. Since I was no longer inhaling carbon monoxide,did I then have more oxygen in the
colon and create a bloom of facultative anaerobes,dont know.
Probably a zillion things going on that I don't know about or am just plain wrong.
But interesting to speculate.
Post Edited (Old Mike) : 9/1/2013 7:27:02 AM (GMT-6)