I have found that it is best to take 2 Apriso in the morning then 2 more about two or three hours later.
The delay before it started to release was about 20 to 30 minutes. Apriso is a time delay long acting
drug, so breaking up the 4 capsules isn't a problem. I could tell when it had released after 20 to 30
minutes because of the short period of gas. When I didn't take the pills I had no gas. So I figured it
had to be the drug. I only take two in the morning now, since I started taking an Indigo herb.
This is only my experience, but you may react differently. Hope it works well for you.