I found this article on a German forum. Sorry if the translation comes out bad:
Go to translate.google.com
and paste this link:www.netdoktor.de/News/Colitis-ulcerosa-Krebsmitte-1138054.html?utm_source=Newsletter+25.10.2013&utm_medium=E-Mail&utm_term=Colitis-ulcerosa-Krebsmittel-als-neue-Therapie&utm_content=4
For some reason it doesn't let me paste the already translated link from Google.
I know the translation is bad but here it is:
Ulcerative colitis: a new cancer drug therapy
Munich (netdoktor.de) - In chronic intestinal inflammation genes also play a role, which are involved in the development of cancer. If it were so-called tumor suppressor genes, found Canadian researchers from the University of Alberta in animal out. This gene are defective malice or no longer work properly, the inflammation process is in ulcerative colitis triggered. In addition, the colon loses its ability to repair its mucosal again - this leads to new infection episodes.
The good news: In the experiment with mice Shairaz Baksh and his team put medicines for blood cancer a. They managed to intervene in the inflammatory process and thus to speed up the healing process of the intestinal mucosa. The scientists were surprised at how well struck the therapy: "Treating the symptoms of ulcerative raised on," said Baksh. And: "By check or prevent the inflammation, we can also reduce colon cancer risk for ulcerative colitis patients." For about half of those affected was developing in the course of their lives tumors in the intestine , triggered by the ongoing inflammation.
Combination therapy in view
In an unpublished study Baksh and his staff are still testing other drugs. The first results are promising, other medicines help in mice against chronic inflammatory relapses. "A new treatment for ulcerative could be a combination of two or three of these drugs," says the researcher. Until these really be used in humans, nor could pass for about five years. This short period is therefore realistic, because the active substances are already approved for other indications.
Chronic intestinal distress
Suffer from ulcerative colitis in particular young adults between 16 and 25 Of age. In Germany, the disease occurs in approximately 6 per 100,000 inhabitants and year. The causes of chronic Gastroenterology are not yet known. It is assumed that the genetic makeup, but also the diet, and certain environmental factors can lead to an outbreak of disease. The symptoms are very individual, but usually include diarrhea, weight loss and crampy abdominal pain bloody. (Lh)
Source: Gordon M. et al. (2013) The tumor suppressor genes, RASSF1A, Is Essential for Protection against inflammation-induced injury, PLoS ONE 8 (10): e75483. doi: 10.1371/journal.pone.0075483