Not sure.. I was just thinking about
it and looking into what Prof Tan had said: That on the surface it may seem like we know a lot about
it but we actually don't. Everything is different when you get into small nano sizes and its all quite complicated. I think he's correct.
Forgetting anything to do with synthetic particles, additives, bacteria etc and just looking at mucus for what it is - just simply a filter.
This shows some pretty decent images of mucus and the scaffold as they seem to call it (though lung) but it's going to be the same or similar in the intestine I would assume. So we have multiple pore sizes on both scales (nano and micro) all mixed in to deal with this stuff (bacteria, food, and so on). www.pnas.org/content/109/45/18355.full.pdf+html?with-ds=yes
"HEC hydrogels with much smaller pore sizes and a higher elastic and viscous modulus were even shown to be penetrated more easily by magnetic particles than mucus. It was discovered that this discrepancy may be caused by differences in rigidity of the polymer scaffold, which was assessed by optical tweezers, and a broad pore size distribution in mucus."
So we have a lot of papers now gathered showing that in people with IBD and colon cancer there is a change in the mucus itself. Even missing mucus altogether in the case of UC and Cancer. And as the above paper points out it's the scaffold rigidity that might the difference. The breakdown of this scoffold being a common theme.
Certain bad bacteria can degrade this stuff (by breaking the cysteine bond), and many papers now suggesting commensals do not degrade this stuff even though some secrete serine and thrionine proteases - BUT at the same time the mucus layer is totally regenerated from start to finish every 20-30 min. The whole thing is replaced. So even bad bacteria and food additives/surfactants only have a small amount of time to get to work on it to even manage to get through. And then look at what they are up against - two types of fluid in multiple layers blocking them, other bacteria trying to kill them, all these micro pores blocking their way, and 10 little phagocytes for every one bacteria sitting there waiting to kill them. That's some serious impediment.
So it all just got me thinking. Maybe we have a basic problem with our filter media.
Are there a few strains of bacteria that can just walk right in and plow through all this stuff and break it down.. Or did something go wrong in us one night causing us to not make our filter media properly anymore? Like inside the cells that make the mucus. And why only in certain areas? What's different about
Was just thinking about
that is all. is it an outside in problem or an inside out problem...
Diagnosed Crohns-Colitis 9 years ago - Past Meds: Antibiotics, Prednisone, Methotrexate, Imuran, Remicade - Current Meds: Pred 30mg/daily and tapering. Imuran 150mg/daily, Natural: WOO/Thyme Oil, All organic food no additives. Reuteri and Plantarum probiotics.
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