Guess I need to restart this thread,first link does not work now.
This one just below on antibiotics scares me a little we all know that antibiotics don't seem to cure UC in most cases or even help much, but as you can see the mucosal biofilm is practically wiped out of life or slowed down.
What scares me is that with the bacteria death or slow down,why don't you go into remission.
The paper did not go into clinical response for these people.
Is there something else going on besides bacteria,causing the inflammation,perhaps the bacteria just went into
spore or some other less active form, or they did not have a FISH probe that lights up all the different bacteria
types, or is it perhaps the presence of the biofilm itself that is causing the immune response.
Perhaps why some people can go into remission just with colonic lavage.
Also notice the massive rebound effect after the antibiotics are stopped.
I can see the rebound as a trigger for UC,but what is going on with a UC biofilm.
In his other papers the bacteria can't get to the mucosa due to the mucus barrier.
In figure 2 and 3 you can see bacteria adhering right to the mucosal surface,seems to be no mucus in the way,
So is it a lack of mucus,or do biofilms have to we washed away also, perhaps in addition to bacteria killing.
guess I need to look more at biofilms and immune response
The host defence discriminates between pathogens and commensals, so colonisation with bacteria does not necessarily elicit an immune response. With our intestinal “microflora” and our skin germs we live in mutual acquiescence. There is even evidence that those bacteria modulate and shape our immune system from early childhood throughout the whole life [69–72]. The bacteria are tolerated because they reside in privileged areas of immune tolerance. This compartmentalization allows a local, but not systemic immune response. The epithelial cell layer and the cytokine micromilieu are essential to maintain compartmentalization. Changes in the composition of the human commensal bacterial microflora could enhance the susceptibility to allergic diseases . Disruption of the epithelial barrier or invasion of bacteria by other means will perturb the friendly coexistence and will activate a host response
Whoa!!!!! if you look at the first set of pictures and read their comments, the biofilm decrease from proximal to the
distal part of the colon, but this was on a dead person.
Descending colon no apparent biofilm. What the hell does this mean in relation to UC.
What does this mean in relation to UC starts distally and in the rectum.
What does this mean in relation to 10000 biopsy paper,where we see biofilms in UC.
If I remember correctly mucus thickness increases distally.
Does this mean we should have no distal biofilms.
This is a gotta read Swidsinski paper never saw it before.
Post Edited (Old Mike) : 11/10/2014 6:37:14 PM (GMT-7)