Maybe its not the " biofilms" per se, but the INNERMOST LAYER (AKA "wall associated bacteria" in this article below)
See this amazing article: http://www.old-herborn-university.de/literature/books/OHUni_book_8_article_3.pdf
- when we take Abx or are under stress: it kills the subsequent layers but not the innermost layer
- so after stress or Abx: we depend mostly on our innermost layer to repopulate the rest of our bacteria
- explains why most get uc after abx or stress
- explains why early uc does not show dysbiosis because the subsequent layers are only just starting to be affected
- explains why uc is genetic since innermost layer comes from our parents bacteria
So if we want to have any chance of succeeding we need to remove that innermost layer and put new stuff in there.
The innermost layer is like the foundation of a building: if its bacterial composition is dysbiotic nothing will hold since the new bacteria (2nd layer) has to cling onto the innermost layer and live symbiotically with it (see the article above), And even if FMTs help initially you have to keep doing them to continue getting results.
Those who are 'cured' by a single course of FMT and don't require maintenance FMTs are the ones who succeed at replacing their innermost layer.
Why don't we get UC from birth if we already have a faulty inner later?
The subsequent layers that form do protect us somewhat because, as you will read in the article, the subsequent layers' free flowing bacteria also affect the bacteria in the innermost layer. So we are "just" keeping things in check. Then along comes ABx or Stress or Pesticidides/herbicides, Detergents and they kill the subsequent layers and its left up to the "faulty" innermost layer to repopulate us. Slowly the dysbiosis deepens further and further. Explains why for most of us the worsening of UC was a gradual process.
I think this is the most convincing theory of UC pathophysiology. Not everything above from this article but an amalgam of many readings. But this article was the light bulb moment with its thorough explanation of wall associated bacteria.
Post Edited (Conquer UC) : 11/22/2014 2:45:49 PM (GMT-7)