Posted 7/15/2014 5:33 AM (GMT -7)
Had three 1/2 years of remission with Remicade. She was in the pediatric drug trial to get Remi approved for UC, and dose was adjusted several times.Stayed with 6mp for most of that time. Reduced the Remi to almost standard dosing, and eliminated the 6mp due to multiple serious infections. Might have brought the trough levels too low, 'cause just when we were gonna stop the Remi, it stopped working. Full flare stopped with Tacro, but side effects also crummy. Landed in hospital, again...60 mgs of the dreaded Pred. That's when reintroduction was tried. 10mgs per kilo, 3 regular loading doses, plus 2 extra within 6 weeks. Symptoms returned as the pred decreased. Levels were tested and were higher than the chart went- the last dose gave her a body rash that took 6 weeks to diminish. Probably has antibodies now, but didn't before. Remi didn't work at all, and docs considered it a failed mechanism. No other biologics attempted till now.
Daughter, 20 diagnosed 1-08 w/ UC
Drug sampling: Asacol, Cortifoam, 6mp,Colazal,Rowasa,PPI'S , Flagyl, Prednisone.Diet not directly impactful.Remi w/adjustments.
Remission 4-09 - 7-13,simply stopped. Remission with Tacrolimus. failed 1/14. Endocort, Uceris,Canasa, hospital, Pred. Pancolitis via scope.Retried Remi,no-go. Entyvio next!