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6mp and nausea

Chronic Illness Forums
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Ulcerative Colitis
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the_engineer
New Member
Joined : Jun 2014
Posts : 6
Posted 7/15/2014 6:36 PM (GMT -7)
Hey everyone, I been taking 100mg of 6mp every day for the past month and I have been getting really bad nausea and loss of appetite. My blood tests have been normal so far. I did some research and some people suggested I take it before bed time but that has not helped. I can only eat in the mornings and then later on through out the day I get really bad nausea and I lose my appetite. For the people who have been taking 6mp, does the nausea stop after a while? Is there anything I can do to help lessen the nausea or stop it?
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Katmom
Veteran Member
Joined : Mar 2008
Posts : 1203
Posted 7/15/2014 7:02 PM (GMT -7)
Wanted to bump it up, in case others may now respond.
Never felt much of anything on that drug....though others have known it worked. My daughter is an easy puker, and fought nausea many times-- landed her in the hospital 3 times-at least- sometimes from acid, once from appendix, sometimes unidentified UC side affects. She only had it in conjunction with Pred or Remi, so hard to separate the side effects.
Daughter, 20 diagnosed 1-08 w/ UC
Drug sampling: Asacol, Cortifoam, 6mp,Colazal,Rowasa,PPI'S , Flagyl, Prednisone.Diet not directly impactful.Remi w/adjustments.
Remission 4-09 - 7-13,simply stopped. Remission with Tacrolimus. failed 1/14. Endocort, Uceris,Canasa, hospital, Pred. Pancolitis via scope.Retried Remi,no-go. Entyvio next!
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Andrina
Veteran Member
Joined : Aug 2011
Posts : 3484
Posted 7/16/2014 3:51 AM (GMT -7)
I've been suffering from bad nausea from Imuran. Adding Cymbalta to the mix didn't help at all so I had to get rid of it.

I went to a nutritionist yesterday. She basically told me to "eat through the nausea" since I'm not really throwing up. However, when I first upped to 150 mg, I was very sick and nauseous for about a month. Thankfully that has gotten better.

I use ginger and crackers when I cannot eat anything else. Some nausea medicine might help too.

I know the general problem with appetite loss. I have it too. I have to force myself to eat and I cannot eat much throughout the day.

Wish I had some better advise.
Diagnosed with UC in '02
Past treatments: Prednisone, Entocort, 5-ASAs, Azathioprine (2.5 yr semi-remission), MTX (6 mo), Remicade (2 yr remission), Humira (8 mo), LDN (2 mo), Uceris (symptom-free within 3 wks)
Currently on 150 mg Azathioprine (Imuran), starting Cymbalta & VSL#3
Diagnosed with Serositis 12/4/2013
Scope on 3/6/2014 showed no inflammation but scarring
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Charlie3
Regular Member
Joined : May 2013
Posts : 293
Posted 7/16/2014 5:38 AM (GMT -7)
6 MP also gave me nausea . even Zofran didn't help . I had to stop it after a month. turn
Joan,81year old Grandmom,DXed in 2012.
Failed meds,Asacol,Liada,Remicade6MP.
I was on & off Prednoisine the past 2years.
supplements,Ultimate Flora 30billion,Caltrate 600d,Immodium a needed
Now on bi -weekly shots of Humira.
Lost over 30 lbs, hard work to gain it back.
This UCIs. A curse on all of us.s ..
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PamSmith
Regular Member
Joined : May 2010
Posts : 245
Posted 7/16/2014 6:50 AM (GMT -7)
I have been taking 6mp for 9 months. I take at night right after dinner. I noticed that if I did not eat well, it gives me nausea. It does get better with time. Did you start with 100 mg? I started with 50mg and then had blood test to check levels and then increased to 75mg. I think it gave time to my body to adjust. I am not in full remission but it is helping.
Current medication: Uceris 9mg 1/day, 6mp 75mg/day, Delzicol 400mg 3x3
Current supplements: multivitamin, VSL #3,Citracal, Vitamin D,Biotin
Diagnosed :crohn's colitis 2010 now changed diagnosis to indetermined colitis(prometheus serology sgi test)
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Andrina
Veteran Member
Joined : Aug 2011
Posts : 3484
Posted 7/16/2014 7:12 AM (GMT -7)
Imuran helps me so I happily trade in nausea for a bleeding colon. It's a lot easier to deal with.
Diagnosed with UC in '02
Past treatments: Prednisone, Entocort, 5-ASAs, Azathioprine (2.5 yr semi-remission), MTX (6 mo), Remicade (2 yr remission), Humira (8 mo), LDN (2 mo), Uceris (symptom-free within 3 wks)
Currently on 150 mg Azathioprine (Imuran), Wellbutrin 150 mg, VSL#3
Diagnosed with Serositis 12/4/2013
Scope on 3/6/2014 showed no inflammation but scarring
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the_engineer
New Member
Joined : Jun 2014
Posts : 6
Posted 7/16/2014 7:24 AM (GMT -7)
Hey Pam, I started off with 50mg for about a month and a half then my doctor increased it to 100mg. I have severe pancolitis so 50mg didnt do much for it. Some times the nausea is so bad that I need to lay down. My doctor said to give it a couple more days and if it gets worse he an switch it to some other kind of 6mp I forgot the name. I havent tried zofran yet, the pills just keep on stacking up one after another lol
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Guardian7
Veteran Member
Joined : Apr 2006
Posts : 2682
Posted 7/16/2014 11:48 AM (GMT -7)
I can't speak for anyone, but personally, I'd rather deal with a full blown flare or pancolitis than be on imuran again.The side effects were so bad that I did not want to exist. Yes, that's an euphemism for wanting to die.

I don't know what to say about the nausea. The worst did subside for me in 3 or so months, but it was a heck of a long wait. I still vomited up food at night, so I don't believe it completely went away.

If you continue to feel bad, I would ditch the 6mp and go for the biologics or some other therapy instead. I don't believe you should have to suffer.

Best.
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Contentprof
Regular Member
Joined : May 2014
Posts : 412
Posted 7/16/2014 10:47 PM (GMT -7)
I agree with Guardian7. Had nausea on 6mp and high fevers too. Couldn't function. Tried it for 6 wks & gave up!
____
Female 55. UC for 10 years, proctitus before then.
Used Prednisone & cortenema for flares--no real improvement.
Tried & failed mesalamine (hives, fever), 6mp (drug fever), uceris.
Remicade every 8 wks (began 12/13) & all symptoms vanished.
Remi premeds: Tylenol, Benadryl, Zofran, phenergan.
Update 6/30/14: severe joint pain; prednisone 40 mg; stopped remicade.
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