Here for your collection you got going OM - Though I don't ever recall coming across anything about
MAP as a cause of Ulcerative Coltis even though it is strange and suspicious that the two diseases cluster and sometimes are mistaken between each other. And the verdict is still out on MAP and Crohn's but it is shown to be capable of infecting human tissue under certain circumstances.
Gary has a thought on here that I personally really, really like - The idea that Ulcerative Colitis is akin to an allergic reaction to a single type or many types of bacteria in the colon. To extend on this line of thinking a little further here:
There is one paper were it implicates MAP "Antigen" as perhaps the cause of the problems - So think just like a person having Celiac Disease and reacting to Gluten but replace Gluten with "MAP Bacteria". The response of T-cells to this antigen perhaps causing the bulk of the damage. This is a really interesting idea and sort of falls in lines with Gary's thoughts on UC being some type of Allergic Reaction type issue where the body would react similar to someone with Celiac but perhaps to another type of bacteria common in the environment or even commencial - So this paper discusses that a little - or the abstract, though form the title you might not think that.
Frequency of mycobacteria reactive CD4 T-cell clones in intestinal biopsies of Crohn’s Disease patients:www.paratuberculosis.info/images/proc11/383.pdf
So this is worthy of some thought perhaps. Ulcerative Colitis being an allergic/immune reaction to a type of bacteria perhaps brought on by an initial or chronic infection - and leads to some type of chronic inflammation/allergic response type thing as a result.
MAP Specific Stuff for your thread:
Is MAP even capable of infecting Human tissue and causing symptoms?:
Mycobacterium avium paratuberculosis Invades Human Small-Intestinal Goblet Cells and Elicits Inflammation
This is a study involving MAP bacteria and the interaction with Human Intestinal Tissue.
“The results of the present study show that MAP bacteria can infect and trigger the innate immune system to elicit inflammation in the immature and germ-free human small intestine.”
Not my words, but Professor Tim Bull's in his lecture on this study: “Samples were taken from human fetal ilium. The fetal ilium were allowed to grow to normal human illiim and they then infected them with MAP.
The results show that in 3/9 Donors there is:
And in 6/9 donors there is:
So yes, MAP can actively invade human intestinal tissue and cause a range of symptoms from no damage all the way to severe inflammation and epithelial damage and seems to be dependent on certain gene mutations present in donors. Work is continuing on this.