Well I finally got the paper from the author,busy doc I guess but very nice as are they all.
Anyhow they mention upfront the disparity between crohns and UC with smoking, but I can't quite figure out if they
actually answer that question,or not, at least directly. But I really don't see and answer. I can only gues
that since nicotine increases mucus thickness/viscosity that this effect is perhaps an over riding factor
For crohns it looks like nicotine might help,patch, gum,but not smoking do to the other metabolites.
Depending on the strain and the immune response differential effects take place.
Now, gee what is the effect on Niacin supplementation/food fortification, on at least crohn's. There was
no food fortification in 1900.
How about all the new foods in the diet since about 1900 which might contain niacin,coffee is a big one.
I am still trying to figure out biologics and MAP, if MAP is a cause how can biologics heal,believe they are more effective
in crohns than UC.
here is one study which discusses mycobacteria infection and biologics, perhaps MAP is just a bystander. At least as of 2010
no MAP level studies in IBD with biologics. Need to look for more later data.
Interesting I found one,MAP antibodies go down with biologic treatment. This now points to most/many
of the IBD treatments, actually control MAP. Since I have had a few it might be worth repeating that
since about 1942 the GI community has inadvertently been treating MAP.
Also there seems to be no nicotine treatment studies on crohns disease,but unpublished data says
it does help chron's patients. This would seem to corroborate the above nicotinic acid study. There is a
nicotine enema study on crohns/colitis seemed to help.
This is all getting curiouser and curiouser.
Huh what: Sober now.
Cigarettes loaded with MAP.
Also of interest flour/grain fortification with NIACIN started in the US about 1938.
Nicotinamide - switch need to look at this much more,what I think it is saying that excess B3/niacin, is turning
off the de novo production of nicotinamide from tryptophan,biochemists here more than welcome to help figure
tryptophan levels and IBD
This is an old study,but now have to wonder if we are eating/supplementing
too many antioxidants. Something defective in iNOS pathway too much arginase,or SOD. If I supplement with arginine,makes the UC worse.
PS: If I have made any errors here, it is due to the margaritas and IPA beer.
Post Edited (Old Mike) : 11/4/2014 5:43:12 AM (GMT-7)