Mild depression caused by Imuran??

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Canada Mark
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Date Joined Jan 2013
Total Posts : 3481
   Posted 8/15/2014 6:42 PM (GMT -7)   
Has anyone on here taking Imuran for a while noticed a bit of depression coming along with it? I feel great symptom wise, in fact have very few if any most of the time now, but I just seem to lack something over the last few months - almost like a mild/medium depression. It's strange and hard to describe.

Was curious if it might be a side effect of Imuran as it's the only prescription I take. Not sure what to do about it. Never had anything like this before really.

TrinitySierra
Regular Member


Date Joined Feb 2012
Total Posts : 168
   Posted 8/15/2014 7:29 PM (GMT -7)   
I was on Imuran for nine months, though I did not have depression symptoms persay, however I did feel somewhat off when I took it. I wish I could describe the feeling more, but like you said, it's strange and hard to describe.

Anything is better then a constant flare! That's how I look at it. If symptoms get worse, have you ever wanted to try an anti-depressent? I've had great results with Lexapro. Helped me through a terrible flare.
Diagnosed in Jan. 2012.
Started Humira on July 30th, 2014. Has helped so far!
Past: Imuran 100 mg, put me in remission for 9 months. However, got side effects so stopped.
For flares: Predisone and Hydrocortisone enemas
Intolerance: All 5ASA drugs and Uceris :(
*Predisone helps get me out of flares, but I get muscle atrophy, and all the other awful side effects that come with it. DEVIL DRUG!

TroubledTurds
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Date Joined Jan 2004
Total Posts : 8038
   Posted 8/15/2014 8:06 PM (GMT -7)   
three stooges
marx brothers
Seinfeld
mel brooks
monty python

etc., etc., ..........

oh yeah, LZ ;-)

Bacon Girl
Veteran Member


Date Joined May 2011
Total Posts : 5474
   Posted 8/15/2014 8:29 PM (GMT -7)   
Hmm ive never experienced this, mark.

For me, remission and depression do not fit in the same sentence. I rarely get sad or stressed about anything these days.

But i take a small dose- 25 mg per day now. Ive been cutting my pills in half since i dont wanna take it!
Joanna Banana, 24
100 mg Simponi every 4 weeks
50 mg imuran daily
21 mg nicotine patch (my savior)
AlgaeCal and Strontium
Curcumin, Astaxanthin (sunburn protection), Probiotics, and Mag Citrate (as needed)


Diet: meat, eggs, fermented everything, and small amount of fiber (less than 2 cups per day).
Symptoms: none. remission since i started nicotine.

iPoop
Forum Moderator


Date Joined Aug 2012
Total Posts : 11050
   Posted 8/16/2014 4:46 AM (GMT -7)   
I don't think imuran is the cause. Any life changes (work, home, relationship, family, friends) or is being sick with uc getting to you?
Moderator ulcerative colitis
M, 35, proctosigmoiditis
Rx: Remicade 5mg per kg, every 8 weeks
Daily 75mg 6MP + Rowasa
Diet: Diet mods and supplements haven't done a thing for me

Guardian7
Veteran Member


Date Joined Apr 2006
Total Posts : 2682
   Posted 8/16/2014 6:07 AM (GMT -7)   
Imuran (and 6mp) made me really tired and sick all the time. Like the didn't even want to get out of bed kind of tired. I don't think it was depression, but it sure felt like it. I guess I was too tired to even feel depressed while on it LOL. My energy returned to normal after discontinuation.

I think the neurotransmitters involved in fatigue play some role in that and possibly work on the same pathway which leads to depression.

I do think more studies are needed to evaluate the psychological side effects of drugs. I think the onus is on pharmaceutical companies to provide complete transparency on the spectrum of side effects (and not just call something a "miracle" drug).

I hope that answered part of your question.

Best.

Sibby
Veteran Member


Date Joined Apr 2010
Total Posts : 1353
   Posted 8/16/2014 4:31 PM (GMT -7)   
Never caused me depression. But like Guardian said, it also caused me not want to do anything because I was always tired. My energy shot up when I was off it.
24 · F · Ont., Canada
Inactive pancolitis UC · Last scope: Mild rectal inflammation
Asthma, lactose intolerant, IBS, migraines, Sulfa allergy, Mucosal Prolapse
5-asa intolerant, Imuran - very low WBC
LDN, 3mg · Alesse 21 · Folic acid, 5mg · Inderal, 10mg · Multiple vitamins
Temp: Cipralex, 10mg, Doxepin, 30mg
'Paleo' diet · with potatoes, peanut butter
Biologics ruled out

Canada Mark
Veteran Member


Date Joined Jan 2013
Total Posts : 3481
   Posted 8/16/2014 8:23 PM (GMT -7)   
Thanks all - I think maybe it's not so much depression, but as others describe - a lack of wanting to do anything.... Get up, always tired, have trouble sleeping at night, just kind of blah feeling. I don't like it. I can't even inspire myself to get out and row or exercise, or clean up etc etc. It's odd.

Though I passed a major milestone this week with a full week (7 days) of perfectly normal formed BM's and no mucus etc whatsoever. Just normal poop usually twice per day- so that's a first in 12 years, which is awesome. But because of this I am reluctant to taper back on the Imuran. Maybe I'll see how the next week goes and consider dropping form 150mg to 100 and see how that goes.

I don't want to push things. I can't quite express how awesome a week of normal poop is....
Diagnosed Crohns-Colitis 10 years ago - Past Meds: Antibiotics, Prednisone, Methotrexate, Imuran, Remicade - Current Meds: Imuran 150mg/daily, Natural: WOO/Thyme Oil, All organic food no additives. Reuteri and Plantarum probiotics.

“The only person you're destined to become, is the person you decide to be"

malaika
Veteran Member


Date Joined Feb 2014
Total Posts : 524
   Posted 8/17/2014 3:18 AM (GMT -7)   
Canada Mark said...
Thanks all - I think maybe it's not so much depression, but as others describe - a lack of wanting to do anything.... Get up, always tired, have trouble sleeping at night, just kind of blah feeling. I don't like it. I can't even inspire myself to get out and row or exercise, or clean up etc etc. It's odd.

Though I passed a major milestone this week with a full week (7 days) of perfectly normal formed BM's and no mucus etc whatsoever. Just normal poop usually twice per day- so that's a first in 12 years, which is awesome. But because of this I am reluctant to taper back on the Imuran. Maybe I'll see how the next week goes and consider dropping form 150mg to 100 and see how that goes.

I don't want to push things. I can't quite express how awesome a week of normal poop is....


That's so brilliant! Definitely a major milestone, congratulations.

I have had extreme difficulty wanting to do anything for the past few months. Even when my depression was at its worst I feel I had more willingness to get up and do things than I do now. I never considered Imuran to be the cause, but seeing as all of you experienced something similar, maybe it is...
Moderate pancolitis since May 2013.
Hospitalised due to severe reaction to mesalazine.
Oral prednisolone twice, IV steroids once, steroid enemas once.

Currently on 75mg 100mg Azathioprine and 400mg Ferrous Sulphate.
Trying to blast this flare with l-glutamine, hemp seed oil, anti-histamines, moringa juice and coconut yoghurt.

srut
New Member


Date Joined Aug 2016
Total Posts : 1
   Posted 8/30/2016 7:48 AM (GMT -7)   
I know this question was asked and answered a few years ago, but I thought I'd post for the sake of people in the future looking for answers to the same question (as I was just doing...). I've got moderate Crohn's. I took 50mg of Imuran daily without any depression issues for 3 years (symtoms weren't always in check, and I still had flares pretty regularly, but they were less intense). about a month ago, my doctor decided to up the dosage to 150mg, because, according to him, 50mg isn't enough of a dosage to actually keep the disease from worsening. Almost immediately, I started feeling depressed. I wouldn't call it complete full on depression, but it's similar to what people above have been describing: lack of motivation to do anything. I've also been having mood swings and feeling lonely and sad. The tiredness is a listed side effect of Imuran, so I expected that, but the other side effects are really becoming a problem, since my poor husband gets the brunt of my mood swings. I spoke to my doctor, and he recommended I stop taking it and that he and I explore other medication options. He says that while it's pretty rare, he HAS seen Imuran cause depression and general lack of motivation before. Hopefully this helps anyone else experiencing Imuran-related depression and wondering if that's normal.

NiceCupOfTea
Elite Member


Date Joined Jan 2010
Total Posts : 10098
   Posted 8/30/2016 8:10 AM (GMT -7)   
Hmm. I have been on 6MP (which is what azathioprine/Imuran gets metabolised into) for a few months now. I wouldn't say my depression has got worse, but my tiredness has. I wake up and it's a major struggle to do anything beyond drink cups of tea and stare like a zombie at a screen for the first few hours. It could be described as listlessness as well. I tend to start waking up from the late afternoon onwards, then have another collapse after dinner; I then wake up again around midnight, which is awesome for going to bed at a reasonable time (not).

It's partly because of that why I have finally started a new antidepressant, duloxetine. It had to be a non-sedating one - I can't afford to be any more groggy than I already am! Too soon to tell what effect it's having yet, apart from lots of nausea... :-/
Dx Crohn's in June 2000. (Yay skull)
Tried: 5-ASAs, azathioprine, 6MP, Remicade, methotrexate, Humira, diets.
1st surgery 20/2/13 - subtotal colectomy with end ileostomy.
2nd surgery 10/7/15 - ileorectal anastomosis. Stoma reversed and ileum connected to the rectum.
Current status: Chronic flare. Do I have any other kind?
Current meds: 50mg 6MP; waiting for funding for Entyvio

Angel&me
New Member


Date Joined Aug 2016
Total Posts : 9
   Posted 8/30/2016 12:01 PM (GMT -7)   
Taking 150 mg but when doc dropped me to 100 mg it caused my current months long flare. Would recommend long hard thinking before lowering dosage. Also, constant fatigue as many have said.
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