iAP has never been on my radar until this week,seem rather important. Cant believe I never ran across it before.
Comes from the brush borders in small intestine found in feces,with UC 50% low.
Detoxifies endotoxin/LPS, unmasks bacteria hiding behind LPS,Iga need to be specific but needs to be able
to read the bacteria,but cannot if masked by LPS.
Not normally made in colon,but found in ulcers,made from mRNA.
Phenylalanine can suppress,that is found in many protein foods,inorganic phosphate can suppress.
Oral iAP can induce remission in humans,no supplement that I can find.
But we can have some control to up regulate with zinc, and oral vitamin K's,possibly onion,butyrate,glycine.
If brush borders are damaged by celiac then you make less.
That's my bottom line so far.
human uc study
what a pain tnf blocks butyrate induction of iAP, this shows why oral alkaline phosphatase might work
tnf has got to go somehow other than biologics, Wellbutrin
Post Edited (Old Mike) : 8/31/2014 6:23:57 AM (GMT-6)