Ok going to start adding stuff here,will see where this goes. If I find something really interesting will bump
with new post. This ROS paper is real interesting,but what I am really looking for is impaired killing,with
excess antioxidants which quench the immune systems bacteria killing chemicals too fast. Might be difficult or not to find info. In crohns for instance they are not only dysbiotic at early onset but there is higher counts of bacteria in the small intestine then there should be,in general. For us we have been penetrated past the mucus barrier.
good paper on ROS and colitis/mice,tregs, cached version
"This argument is completely opposing the traditional concept that ROS is involved in the induction and progression of IBD . According to the traditional concept, anti-oxidant intervention should be effective in the treatment of IBD, and large array of antioxidant compounds have been shown to be protective against IBD in experimental animals. Nonetheless, objective clinical data supporting anti-oxidant intervention of human IBD are still scarce ."
another good one human
The likely explanation is that free radicals aren’t as evil as advertised. (In fact, people need them to kill bacteria and eliminate new cancer cells.) And when people take large doses of antioxidants in the form of supplemental vitamins, the balance between free radical production and destruction might tip too much in one direction, causing an unnatural state where the immune system is less able to kill harmful invaders. Researchers call this the antioxidant paradox.
periodontitis-this almost sounds like UC of the mouth
antioxidant status of people with peri is lower,which may sort of refute my case here,but
wonder if there is an alternative explanation, I don't have one but there might be one.
seems again a biofilm that is not easy to clear
This one might be a must read:
well here is a different take;hard to kill p.gin
crap this could even explain some of the stuff going on with UC
inos and mucus thickness
never saw this one,seems to support the mucus breach theory
mice diet and dss
france low food fortification sunlight study,lowers crohns incidence but not uc
this say in IBD cats high antioxidant status is decreasing inflammation.
Ok but does that really imply that the inflammation went down do to increased quenching
of oxidative bursts and less bacterial killing efficiency.
oxidation and NF-KB
here is the one on gray/white hair
Post Edited (Old Mike) : 12/6/2014 7:08:42 AM GMT