Lots of people reported problems after they had to switch off Asacol. So that does say people might be sensitive to time-release method and buffers. Usually though it is one from working a bit better than others - not usually a case of tolerance.
How long did you try Lialda and how active was your flare at the time?
If you can find a mesalamine that works, it is generally a lot better than the other drugs.
Post Edited (DBwithUC) : 12/13/2014 9:19:52 AM (GMT-7)