Good luck on your infusion. Sounds like remicade/infliximab is a pregnancy category B drug, fairly safe, but some unknowns.
- Category A: Controlled studies show no risk or find no evidence of harm.
- Category B: Animal studies show no risks, but there are no controlled studies on pregnant women.
- Category C: Animal studies have shown risk to the fetus, there are no controlled studies in women, or studies in women and animals are not available.
- Category D: There is positive evidence of potential fetal risk, but the benefits from use in pregnant women may be acceptable despite the risk (i.e. life threatening condition to mother)
Pregnancy and ibd (from the resources thread)onlinelibrary.wiley.com/doi/10.1002/ibd.20532/pdf
Biologic TherapyInfliximab, a pregnancy category B drug
, is approved for the management of CD and UC. Infliximab is an IgG1 antibody, which does not cross the placenta in the first trimester, but very efficiently crosses the placenta in the third trimester. While this protects the infant from exposure during the crucial period of. organogenesis, infliximab levels can cross easily in the third trimester and therefore be present in the infant for several months from birth. There is a growing body of evidence that suggests infliximab is low risk in pregnancy.
6-Mercaptopurine (6MP) and its prodrug azathioprine (AZA/Imuran) are pregnancy category D drugs.
Well, steroids are category C, so by that logic, she's much better off on Remicade. I was on Apriso my entire pregnancy, and I'm pretty sure it's also category B. That article is from 2008, so there's been a lot of time to collect further evidence about
the effects of Remicade on the baby.
Honestly, pretty much all drugs are at least category B, because there just aren't that many controlled studies on pregnant women.