Well searching around long enough I ran into a patent by Dr. J Pravda who wrote the radical induction theory.
This is not just some guy off the street, he works here.
Inflammatory Disease Research Centre, West Palm Beach, FL
Tuff read but possibly what is really going on,we are being oxidized first,which sets up the defect in the mucus barrier,then leading to polymicrobial bacterial invasion, bringing in immune cells and cytokines, which then generate more hydrogen peroxide and the more depletion of antioxidant enzymes and tissue destruction.
I also have found that high levels of TNF-A, induce high levels of peroxides.
There also might be a genetic component, which is of course not good.
The patent is so long have not finished it yet.
Please, please, please read this stuff even it is over your head.
This first paper on the RIT radical induction theory, is not to difficult.
Bottom line of all this is that we need to improve are endogenous antioxidant defense, with at least
R-lipoic acid and NAC and perhaps glutathione,and anything else we come up with.
Not sure I agree with vitamin E, seems to inhibit glutathione transferase.
Yes in the past have taken ALA or NAC but not together,
Right now taking NAC, for the last month or so, seems to be helping.
Will have to add ala.
I am not noticing mucus thinning.
Why do I want you to read this stuff.
The explanation looks like what might really be going on in our guts.
Possibly the answer to why UC generally starts in the rectum, we have been looking for this for years.
It is in the middle of the patent, there is more stuff then I have listed here.
The greatest risk factor for ulcerative colitis is the presence of a rectum. Within this area of the colon a junction of physiological parameters converge to increase the potential for H2O2 generation and oxidative tissue damage (induction). Studies have shown that the reducing power (antioxidant capacity) and GSH synthetic rate of the rat intestine decreases distally, reaching its lowest level in distal colon when compared to the proximal small intestine (Blau, 1999). The reducing power of the human gastrointestinal tract likewise decreases from stomach to colon (Roediger and Babige, 1997). The reducing power of the human colon is significantly decreased when compared to the liver with levels of major anti-oxidant enzymes (catalase, superoxide di****ase and glutathione peroxidase) being 4, 8, and 40% of hepatic values respectively (Grisham et al., 1990). However, rectal epithelial cells have the same complement of enzymes, i.e., cytochrome oxidase, xanthine oxidase, etc., as the liver for use in metabolism of foreign substances including alcohol and xenobiotics (Roediger and Babige, 1997). One by-product of this metabolism is hydrogen peroxide that the rectal epithelium is ill equipped to deal with if produced in excess. Un-neutralized excess H2O2 may diffuse to the extracellular space and induce oxidative damage to the colonic epithelial barrier thereby increasing its permeability to luminal bacterial antigens. Any substance found in the body which, through its metabolism, can give rise to hydrogen peroxide in rectal epithelial cells is a positive risk factor for ulcerative colitis induction.
As you might guess, I am real excited about this.
You really need to read the whole patent there is tons of stuff as dietary risk factors,ect.
Post Edited (Old Mike) : 2/11/2015 8:01:10 AM (GMT-7)