I got to thinking about
what you said in regards to your Grandfather and TB and was poking around.
There is a newspaper article which can be found by searching the title "Scientist finds surprising links between arthritis and tuberculosis" that was an interesting read. Turns out the full study is here, but the newspaper article explained things better: Is rheumatoid arthritis a consequence of natural selection for enhanced tuberculosis resistance? www.ncbi.nlm.nih.gov/pubmed/15082117
So do search the newspaper article title and read it because it gives some background information that is not in the full study.
There is also a follow up study to the above: Autoimmunity and tuberculosis. Opposite association with TNF polymorphism www.ncbi.nlm.nih.gov/pubmed/15693080?dopt=Abstract
The results show an opposite association of TNF polymorphism with autoimmunity and TB, and suggest the existence of heterozygote advantage, sustaining the hypothesis that autoimmune diseases are a consequence of natural selection for enhanced TB resistance. Data also provide genetic evidence supporting the common variants/multiple disease hypothesis, which emphasizes that many disease genes may not be disease-specific, and that similar immunogenetic mechanisms underlie autoimmune diseases.
Not sure if it falls off the map at this point or if others have followed up on the line of thinking.
Anyway, in light of your comment, along with the information Dr. Behr presents and the genetic study showing the shared genetic overlap between both Crohn's and Ulcerative Colitis and mycobacterial related genes - and the genetic overlap between other diseases such as Rheumatoid Arthritis, MS etc and mycobacterial related genes it was all sort of interesting. The strange correlation.
It's also kind of interesting that Canada has one of the highest rates of IBD (both Crohn's and Ulcerative Colitis) and we also have one of the highest, if not the highest rates of Multiple Sclerosis. And there's some question at the moment as to the role of MAP and MS or mycobacteria response and MS.
Seems there's is a also some more recent papers on true Colonic TB or Intestinal TB misdiagnosis for both Crohn's Disease and Ulcerative Colitis being a lot higher than what is realized.
Anyway - bit of a ramble here - but the two diseases (Crohn's and Ulcerative Colitis) just share such a common timeline and incidence etc.
I forget what I was talking about
now - but I guess just the older study above or theory presented suggesting certain "autoimmune" diseases may be the result of natural selection for increased resistance to tuberculosis was very intriguing and different. Never heard of it before - or the suggestion.