It will and it won't...
Mycobacteria in general might. U-Biome uses 16S rDNA to identify the various phylums and classes as best as they can. You probably won't see the words 'mycobacteria' but you will probably see 'Actinobacteria' - so look for this heading. This is the Phylum for mycobacteria.
Now there are a lot of different species of 'actinobacteria' however and this is sort of the problem with these tests... they don't drill down specifically.
To separate and identify MAP specifically from this they would have to probe is with an IS900 primer. Professor Herman Taylor (the MAP vaccine guy) is the one that developed this identification method. The issue it seems is that this genetic sequence also can cross-identify with other mycobacteria (Avium etc). So it says yes this is mycobacteria, and MAYBE it's MAP but it could be mycobacterium avium or another mycobcacteria as well. From here they now also probe things for, or with what is called an f57 sequence. If IS900 says yes, and f57 says yes then there is a very high probability it is specifically mycobacterium avium subspecies paratuberculosis.
What these guys (in the paper) and others are saying is that this then breaks down further where the individual strains of mycobacterium avium subspecies paratbuerculosis seem to have specific genes that may alter their disease causing ability - or virulence. And they are saying that the isolates they have seem to share genes with the cattle version but slightly different. So maybe a mutated version... more specific to a human host versus a cow host.
What I leaned this week from a quick conversation was that they are also questioning the IS900 detection. There is speculation based on a few recent findings (from John Aitken in New Zealand) that the 'human' MAP might be a little different (genetically) because of the form they are in (Cell wall deficient form). So they think ultimately there will be a better and more specific way to detect them instead of IS900 or f57, and because of this, there is still a lot of discrepancy and missed findings at the moment.
Anyway - I remember Dr. Zang asked a question a while ago where he said if MAP requires mycobactin to be added to a culture in order to get them to grow - and mycobatin is NOT found in human blood - how are they capable of surviving and growing in us? This shows that this particular 'human' isolate strain does not seem to require mycobactinas long as the nutrients in the culture media are right - and this strain came from a patient with Ulcerative Colitis.
Now that does not mean in any way that it IS causing the disease, but it sure will be interesting to see where thing go with this in the near future. - And of course it's pretty darn suspicious looking given all the findings going on with MAP and genetics recently.
Of note I am told it is also isolated from Rheumatoid Arthritis patients. So they are saying they now strongly think that RA is a co-morbidity or associated condition. My family history:
My grandmother - Rheumatoid Arthritis
My grandfather - Ulcerative Colitis
My mother - Rheumatoid Arthritis
Me - Crohn's-Colitis
My family doctor just to me a few weeks ago that it's the mothers side that is important really... Not sure if this is true or not, but the history on that side is there. My fathers side has none of these.
Post Edited (Canada Mark) : 10/5/2015 10:08:30 AM (GMT-6)