Casey_LB is right, it's a statistical trick -- like saying if you're looking for a lost item, "it's always in the last place you look." Statistically speaking, if you fail treatment, that makes it more likely that you have aggressive disease and that subsequent treatments won't work as well. The direction of causation runs opposite to what the nurse implied (it's not that switching biologics makes you less likely to respond, it's that if you switch it's probably because your disease is poorly controlled and therefore less likely to respond to any treatments).
it this way: if I told you that person A has been on Remicade for ten years and person B has tried Remicade, Cimzia, Simponi, Humira, and three study drugs, just based on that information, who would you think is doing better?
dx'ed UC pancolitis 5/12
past meds: asacol hd, VSL#3, apriso, rowasa, xifaxan, 6mp, cortifoam, pentasa, cimzia, canasa, butyrate, flagyl, cipro, prednisone, remicade, methotrexate, cholestyramine, cortenema
current meds: none!
step one: colectomy, end ileo 1/16/13
step two: j-pouch construction, loop ileo 5/1/13
step three: takedown 7/31/13