unfortunately, there are no absolute right answers to your questions -
it could be your symptoms have just gotten worse in spite of the drugs - or it could be as you say, your body has become intolerant of the mesalamine - it does happen -
how many times a day are you going ? do you have urgency also ?
i tend to take risks and make bad decisions sometimes - but sometimes those risky decisions turn out ok - so it all depends on what kind of person you are when it comes to deciding whether to stop taking the asacol or not -
are you using any rectal meds at this point ?
dx'd with pancolitis 12/21/03
current supplements:probiotics, vit D, cal/mag, Psyllium Seed powder/Heather's Acacia fiber/ L-Glutamine/Hemp powder slurry 1x/week - grain free/paleoish diet that includes 100% grass fed beef, raw goat milk, & local eggs, lots of all natural well water, exercise, sleep as much as possible & enjoy this great life that God has blessed me with