And many of us get relief and find remission through biologics. I've achieved remission this way, and have yet to experience a side effect. There are many treatments available for uc, and I'm big into dispelling the fear and misinformation that sometimes accompanies them. Risks versus benefit analysis and looking at the actual odds was particularly helpful to me. There are serious side effects with biologics, but statistically small odds. Infact, Mesalamine carries many equally small but serious side effects (heart swelling, kidney inflammation, liver inflammation, as well as blood abnormalities) that are often overlooked and not discussed with the same voice. Yet for the biologics these equally small and rare side effects are big reasons for not taking them. It seems a bit unfair/biased to claim the mesalamines are safe yet biologics are not.
Not everyone needs biologics, and as such they're a third line of treatment after both mesalamine and immunomodulators. However in many aggressive and severe cases biologics make a lot of sense, are effective, and give a big improvement to the quality of life in those patients. There are risks, and they need to be fully understood before starting. However, the benefits often far outweigh those risks. And if recent clinical evidence (like a c-scope as often is the situation) suggests that a biologic is the best course of action then I'm not as quick to dismiss it.
If everyone could manage their uc through a simple, easy to follow diet modification plan then there would be no need for uc medications. Uc is very individual, what works for one doesn't necessarily work for others. So my hats off to those of you can manage that way. It'll never work for me or many others though.
Moderator Ulcerative Colitis
John, 37, UC in histological remission
Rx: Remicade @5mgs/kg/8wksWords containing "UC" both literally and figuratively: sUCk, ouch, deuce, mucus, f-ed, lucifer, and luck.
Post Edited (iPoop) : 3/30/2016 7:33:33 AM (GMT-6)