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GSE and Biologics

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Ulcerative Colitis
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Posted 4/5/2016 11:47 AM (GMT -8)
This is sort of a part 2 to the other thread I posted, but I wanted to get more specific.

Has anyone used grapefruit seed extract while on a biologic (could be remicade, humira, entyvio, etc.)? If so, was there any bad reaction between the two that you could discern?

One of my clients is concerned that somehow the GSE she wants to take will somehow mess with her etyvio and she'll get horrible inflammation again. I'm not sure what to advise because I didn't resolve my UC with GSE.

Thanks again :)
Posted 4/8/2016 7:39 AM (GMT -8)
You need to do legit research and not ask this on an anonymous online forum.
You cannot give information to your clients based on what is posted here. If you don't have an answer and legitimate research to check with. Than tell your client.
Posted 4/8/2016 12:00 PM (GMT -8)
Grapefruit isn't compatible with many meds and your client is obviously very astute to ask that question. Maybe you or she should ask a real doctor about Entyvio with grapefruit.
Posted 4/8/2016 12:14 PM (GMT -8)
yes, don't ever trust anything here posted by all of us fake doctors -

only real doctors have all the answers !

now someone please remind me again why we have this forum ?????
Posted 4/8/2016 2:00 PM (GMT -8)
(Well said Dikid.)

Gathering information from forums is fraught with danger. People usually give opinions, and anecdotal information, sometimes passing them off as if they were facts. Often, ill informed and poorly qualified remarks are made. It is indeed risky to base any recommendations upon this sort of information.


GSE is touted as a 'natural antibiotic'. That is a questionable title.

The process for making GSE involves many steps, generally including the use of food grade ammonium chloride and at a later stage, hydrochloric acid.

The final product is made of approximately 60% diphenol hydroxybenzene (a quaternary ammonium chloride).

It is actually the contaminants that are believed to provide the antibacterial properties of GSE. Some studies have shown that a truly natural extract of grapefruit seed has no antibacterial properties.


People often confuse GSE with grapefruit juice, which has been shown to affect metabolism, and therefore plasma concentrations of certain medications.

The interactions of all compounds are highly complex, and require a great deal of research.
Posted 4/8/2016 3:48 PM (GMT -8)

juststud said...
yes, don't ever trust anything here posted by all of us fake doctors -

only real doctors have all the answers !

now someone please remind me again why we have this forum ?????

I was not saying that this forum is not valuable. But there is a difference between asking advice and checking with doc and using info here for your clients.
How would you feel if your doc came on here and based his responses to your questions from what is here.
When ppl give medical advice I know that have a unique perspective of being involved and they might come up with something that my doc didn't mention but I will check with my doc before changing things

If you come on here and blindly follow the advice that is posted you may harm your self.
Remember drinking your urine? Or other ludicrous posts?
You need to be cautious when following others advise.

I really hope I did not offend anyone as that was not my point. I just think people need to excersize caution as not everything read online is true. I am sure I made mistakes in here.
Posted 4/8/2016 4:03 PM (GMT -8)
There was the poopshake guy too... Although I think fmt is better...
Posted 4/9/2016 8:37 AM (GMT -8)
There are 2 different items i've heard of that people call GSE, one is grapeseed extract (garylouisville was very interested in this). The other is grapefruit seed extract.

I am not sure which you're asking about but I agree with Dikid to some extent. Perhaps you should tell your client to come here and post his/her own questions. Seems like really poor practice to pass along this type of information to clients.
Posted 4/9/2016 9:26 AM (GMT -8)

the OP said...
Has anyone used grapefruit seed extract while on a biologic (could be remicade, humira, entyvio, etc.)?

Posted 4/9/2016 9:42 AM (GMT -8)
Yes, i saw that. I was not sure whether he assumed grapefruit seed because the person said GSE or if the person specifically mentioned grapefruit seed.
Posted 4/9/2016 9:58 AM (GMT -8)
Why are people so confrontational and rude here, especially when it comes to alternative medicine? I haven't done anything to offend you guys and so far in both threads I've posted, people spend more time questioning my intelligence instead of just being polite and trying to help answer the questions I have posted.

Did I say anywhere that I am ONLY gathering information from forums? It's just one more information resource to probe into, but not the only one. So please stop trolling my threads with your personal attacks? It's not fair to me or anyone else.
Posted 4/9/2016 10:03 AM (GMT -8)
The bit on GSE being toxic has been debunked for years now. The LD50 of triclosan and benzenes are so low that if they were present in GSE they would be causing adverse effects at the recommended therapeutic dose (>600mg). So I'm not concerned about that, and that's not why I'm posting. This isn't a, "Is GSE toxic or not" thread. If you want to discuss that then please make another thread.

I'm asking about people's experiences using GSE in conjunction with a biologic. I know that GSE is a CYP3A4 inhibitor, but most TNF-a inhibitors are CYP3A4 inducers, which means, technically, they could balance each other out. But it probably depends on the person.

There is very little clinical data on this, especially with Entyvio because it's one of the newer biologics.
Posted 4/9/2016 10:05 AM (GMT -8)
Btw, the proper name is "grapefruit seed extract", as it comes from grapefruit, which is why it acts on CYP3A4 like all the citrus family does.
Posted 4/9/2016 12:13 PM (GMT -8)

Chiron said...
Why are people so confrontational and rude here, especially when it comes to alternative medicine? I haven't done anything to offend you guys and so far in both threads I've posted, people spend more time questioning my intelligence instead of just being polite and trying to help answer the questions I have posted.

Did I say anywhere that I am ONLY gathering information from forums? It's just one more information resource to probe into, but not the only one. So please stop trolling my threads with your personal attacks? It's not fair to me or anyone else.

I don't know who is trolling you, but if you have a problem with a specific user, you're welcome to email the board admin or any of the moderators and we will look into it. I have barely any familiarity with you so I hope you're not talking about me.

I personally don't care if you want to taut alternative medicine. I only care if you're a medical practitioner offering advice, because that is against the rules of this forum.

So in that vain, if you're using information here to gain "clients" or treat "patients", I think that's teetering on the edge of a violation. Just my opinion.
Posted 4/9/2016 4:51 PM (GMT -8)

notsosicklygirl said...
I personally don't care if you want to taut alternative medicine. I only care if you're a medical practitioner offering advice, because that is against the rules of this forum.

So in that vain, if you're using information here to gain "clients" or treat "patients", I think that's teetering on the edge of a violation. Just my opinion.

That's not what I'm doing and there's no evidence that I'm doing that. I only mentioned my status as a health practitioner because I was trying to frame why I'm here, and the research I'm doing.

Anyway, this thread is a lost cause... it's been turned into one big discussion about me and how I'm irresponsible, and how I should refer my clients to a "real doctor". *eye roll*

I just wanted info from other people's experience. I'm also a UC survivor so it matters to me personally. But it's so adversarial here, it's unbelievable.

The other thread is going well so I'll focus there. Thanks for your time, those of you who tried.
Posted 6/19/2022 2:31 AM (GMT -8)

Chiron said...

notsosicklygirl said...
I personally don't care if you want to taut alternative medicine. I only care if you're a medical practitioner offering advice, because that is against the rules of this forum.

So in that vain, if you're using information here to gain "clients" or treat "patients", I think that's teetering on the edge of a violation. Just my opinion.

That's not what I'm doing and there's no evidence that I'm doing that. I only mentioned my status as a health practitioner because I was trying to frame why I'm here, and the research I'm doing.

Anyway, this thread is a lost cause... it's been turned into one big discussion about me and how I'm irresponsible, and how I should refer my clients to a "real doctor". *eye roll*

I just wanted info from other people's experience. I'm also a UC survivor so it matters to me personally. But it's so adversarial here, it's unbelievable.

The other thread is going well so I'll focus there. Thanks for your time, those of you who tried.


I was about to start grape seed extract. I didn’t know there my be interactions with entyvio
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