Actually the mesalamine you take now already has rare risk of serious side effects (inflammation of liver, kidneys, heart, and blood abnormalities). There's risk in many things we do but as long as that risk is low we don't often think about
it. Other things have risk that we don't often consider like death in a car crash is 1 in 133 odds, risk of death due to heart troubles is 1 in 5. Risk versus benefit is always an important consideration.
Uncontrolled uc inflammation is far more dangerous than the side effects of immunomodulators or biologics. It's mostly about
risks versus benefits. Immunomodulators have 70 percent odds of improving your uc symptoms and the risk of serious side effects are less than 1 percent.The Crohn's and Colitis Foundation of America has great information on this that I found helpfulprograms.rmei.com/CCFA139VL/presentation/player.html
We all have risk tolerances and there's times when you legitimately need to take a risk. With chronic illness, quality of life is the biggest goal. Uc can get worse over time, and it's necessary to update your treatment plan accordingly. Simmering inflammation isn't a good thing as it increases our risk of uc spreading in extent and severity, and increases the risk of flares and colorectal cancer. While being in a deep remission has been shown to provide the longest periods without uc symptoms, less frequent flares, less severe flares, and the best quality of life. So, I wouldn't be afraid of the next step in uc treatment whether that's immunomodulators, biologics, or even surgery. Uc needs to be controlled and managed. And I sincerely believe that our own hesitation to take that next step, only prolongs our suffering from our horrible uc symptoms. Yeah you might not be doing badly, but how much better would it be to forget about
uc due to a solid remission?
Moderator Ulcerative Colitis
John, 37, UC in histological remission
Rx: Remicade @5mgs/kg/8wksWords containing "UC" both literally and figuratively: sUCk, ouch, deuce, mucus, f-ed, lucifer, and luck.
Post Edited (iPoop) : 4/8/2016 8:18:04 AM (GMT-6)