"In fact, another name for corticosteroids is glucocorticoids in honor of the powerful effect they have on glucose (sugar) metabolism.
Prednisone induces elevated glucose levels by stimulating glucose secretion by the liver as well as reducing glucose transport into adipose and muscle cells. The overall effect is a reduction in glucose clearance. Elevated glucose levels can lead to glucose toxicity further impairing insulin secretion from the pancreas
. Prednisone can also impair GLUT-2 expression. GlUT-2 is a protein mediated glucose transporter that ferries glucose across cell membranes."blog.joslin.org/2014/02/how-prednisone-affects-blood-sugar/
"Type 2 diabetes is where the pancreas fails to produce enough insulin, the hormone that helps glucose enter the cells where it can be used as energy. If there is not enough insulin, excess sugar builds up in the bloodstream, causing symptoms such as excessive thirst, weight loss, hunger and fatigue."www.dailymail.co.uk/health/article-1361652/How-steroids-diabetes.html
"Did steroids bring on my type 2 diabetes?
There has been debate as to whether corticosteroids are a cause for diabetes or whether steroids advance the development of existing type 2 diabetes. A study published in 2012, carried out by the University of Sydney, looked to investigate answers to the question. The study, titled Steroid-Induced Diabetes: Is It Just Unmasking of Type 2 Diabetes?, found that those which developed new onset steroid induced diabetes had lower risk profiles than is typical of people with type 2 diabetes."www.diabetes.co.uk/steroid-induced-diabetes.html
Moderator Ulcerative Colitis
John, 38, UC in histological remission
Rx: Remicade @5mgs/kg/8wksInvisible illness: Wow you look great, did you loose weight? Me: I lost 20 pounds in a month through this great new program called IBD and I wasn't even hungry! All I had to do was be doubled-over in pain and have frequent diarrhea. You should try it.
Post Edited (iPoop) : 6/15/2016 1:36:42 PM (GMT-6)