expanded allogenic MSC stem cells seem to hone in on gut and regulate immune system - they do not regrow colon's. Maybe regrow/repair immune system. How they "regulate" is not well understood, nor how long treatment will last.
the therapy is one of the 4 or 5 stem cell therapy approaches reviewed last year:www.ncbi.nlm.nih.gov/pmc/articles/PMC4369491/
"MSCs seem to be a promising therapeutic strategy for IBD because of their ability to selectively home in to injury/inflammation areas after systemic administration, and their immunosuppressive and tissue healing properties[30,31]. However, the clinical data published about
MSCs transplantation in IBD patients showed conflicting results. An explanation for these inconsistent results could be the different sources used to obtain the MSCs that could have distinct differentiation and regeneration capabilities and the variety of protocols used for their isolation and culture. A better understanding of the MSCs biology and mechanisms of action and the exploration of other sources of stem cells in preclinical models of IBD are necessary."
"Experience in UC is even smaller, and was mainly obtained in Russian studies about
response of clinical activity, changes in the pattern of systemic cytokines and elimination of cytomegalovirus after Mesenchymal stem cell transplantation (MSCT). The most important work in this field is a phase III study that plans to include 330 patients who will be treated with MSCs at different doses, but final results are not expected until 2018. "
"It is obvious that MSCs are a promising tool in the treatment of IBD. However, a large amount of work remains to be done to understand the mechanisms through which MSCs regulate the immune system, homeostasis and tissue repair."
11/08: ischemic colitis and scope perf colon. 12cm colon/ileocecal resected. IV antib:sepsis.
01/10: Dx: Mod. UC pancolitis
. Rx: Lialda 3x.
02/11: Major flare w/antib:sinus. Rx: 40mg Pred taper.
07/11: Histol remiss rt/trans; worse sigmoid. Rx: Rowasa & hydrocort
Curr: 1-2 soft-formed stool, no urgency: Lialda 2x, NO PRED, probiotics, Vit-D/C