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amino acids

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Ulcerative Colitis
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richard neville
New Member
Joined : Aug 2016
Posts : 1
Posted 8/1/2016 3:24 AM (GMT -8)
Articles on l- arginine i find confusing. The suggestion that it can cause extra diarrhea in colitis, i have experienced the reverse, albeit i use l-Citrulline, powder, pharmaceutical grade.
Firstly, i have had Pan- UC for about 5 years,terrible disease. The anti-inflammatories, , Mesren/pentassa, made me exhausted, caused a chronic cough, and damaged my testosterone production.
On research, the enteric coating used, known as Phythalates, are toxic. They were banned from use in babies bottles and even water bottles and toys. so why are we given them? Maybe we don't matter. I stopped taking them after going onto D3.
I controlled my colitis with high dose Vit D3, 40,000 IU, split dose, 1st 18 months , then gradually reduced. After nearly 3 years, i take just 10,000 IU. It controlled it very well, but did not cure, inflammation still showed on endocopy, albeit much reduced, over the years.
I would suggest i have actually cured colitis, i have over the last 8 months, used amino acid, an essential amino acid, L-Tryptophan, powder, much cheaper than tablets, plus i took high dose, 10 -15 grams daily, again split.
I recently, after 6 months on L-Tryptophan, had a sigmoidoscopy, to remove what was described as a Nalm, a polyp. On viewing camera inside, inflammation was gone, albut last couple of inches. Polyp came back from testing, as no inflammatory markers, brilliant news. I recon i have now totally cured with continued tryptophan, i did use tryptophan tablet, 1g, inserted in rectum,as a suppository, about 10 times over a month, and it albut stopped urgency, by now nearly gone.
Now back to L Arginine, i use again, powder, again, pharmaceutical quality, L Citrulline, just recently introduced.
Research seems to indicate problems with high dose, (diarrhea) i used about 15g, divided.
Stools went from slightly loose, nearly normal, to normal, plus peristalsis, (normal bowel action/muscle) returned, brilliant.
I have always been using fibergel at least twice daily for years, to ensure i never get any stasis in bowel.
The bodies use of amino acids are extremely complex, it appears they are ignored by the British NHS, in my case, i would say, amino acids, especially L Tryptophan, is the answer, look it up, tryptophan and colitis/chrones.
My consultant commented in a letter to my GP," this patient is controlling his Colitis with Tryptophan", as if to suggest he was aware of it's potential!
My experience with Colitis has been horrendous, articles i have read are even worse, my sentiment is everything is about cause and effect, i would suggest the cause of colitis, is the inability to absorb sufficient amino acids, in the case of Tryptophan, an essential one, and difficult to get the body to absorb this, especially once any bowel disease. All this can be done using doing this as a "Complementary supplement", what do you have to loose?
i purchase these on line, tablets much too small a dose, consequently very expensive, powders brilliant value.
Good luck, by the way, i am not medically trained, just trying to be a survivor, and i would say, achieving just that!
There is a cynical view of all this, and i am cynical, being 67, and that is the American pharmaceutical industry, managed once to ban tryptophan, they cannot patent it, basically they do not want us to use such substances, basically, it's part of food/protein, can that be a bad thing?
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DBwithUC
Veteran Member
Joined : Feb 2011
Posts : 4545
Posted 8/1/2016 8:51 AM (GMT -8)
Well these substance are being researched. The are linked to reduced symptoms (not to remission) in animal models of DSS colitis (which is similar but not the same as IBD.
One 2010 study noted:

"tryptophan reduced the expression of the pro-inflammatory cytokines tumor necrosis factor-alpha, interleukin (IL)-6, interferon (IFN)-gamma, IL-12p40, IL-1beta and IL-17, as well as IL-8 and intracellular adhesion molecule-1, and resulted in increased expression of apoptosis initiators caspase-8 and Bax. "

In the US federal research dollars are available for these lines of research. You may be correct that pharmaceutics companies are not motivated to research amino-acids because the have patent difficulties. But that is the nature of for-profit medicine. Pharmaceutical companies are not obliged to research the cure to disease, although many do.

The National Institute of Health, the CDC, and many non-profit Colitis foundations are obliged to research (or fund) the cure of diseases.

I see no need for conspiracy type of thinking. I don't see any pharmaceutical companies lobbying to block funding of amino-acid research with government funds, nor do I see any attempts to block publication of this research.

I would caution against overgeneralizing form you case. It sound like you controlled D with Vit-D, which can cause constipation. I note you still had inflammation. You then got some alleviating benefit form two different amino-acids.

Good. Great news for you, and others may want to try these supplements. But results may vary. That's why we value controlled research.

Also, just a quibble, but you misuse the word cure. You have achieved effective management and sustained remission with continued ongoing treatment with amino-acids. Unless you can demonstrate that remission persists without relapse after stopping amino-acid it is not a "cure" in the usual sense of the word.

I hope your good results continue.
profile picture
Hambo88
Regular Member
Joined : Feb 2018
Posts : 266
Posted 1/21/2022 12:45 PM (GMT -8)

richard neville said...
Articles on l- arginine i find confusing. The suggestion that it can cause extra diarrhea in colitis, i have experienced the reverse, albeit i use l-Citrulline, powder, pharmaceutical grade.
Firstly, i have had Pan- UC for about 5 years,terrible disease. The anti-inflammatories, , Mesren/pentassa, made me exhausted, caused a chronic cough, and damaged my testosterone production.
On research, the enteric coating used, known as Phythalates, are toxic. They were banned from use in babies bottles and even water bottles and toys. so why are we given them? Maybe we don't matter. I stopped taking them after going onto D3.
I controlled my colitis with high dose Vit D3, 40,000 IU, split dose, 1st 18 months , then gradually reduced. After nearly 3 years, i take just 10,000 IU. It controlled it very well, but did not cure, inflammation still showed on endocopy, albeit much reduced, over the years.
I would suggest i have actually cured colitis, i have over the last 8 months, used amino acid, an essential amino acid, L-Tryptophan, powder, much cheaper than tablets, plus i took high dose, 10 -15 grams daily, again split.
I recently, after 6 months on L-Tryptophan, had a sigmoidoscopy, to remove what was described as a Nalm, a polyp. On viewing camera inside, inflammation was gone, albut last couple of inches. Polyp came back from testing, as no inflammatory markers, brilliant news. I recon i have now totally cured with continued tryptophan, i did use tryptophan tablet, 1g, inserted in rectum,as a suppository, about 10 times over a month, and it albut stopped urgency, by now nearly gone.
Now back to L Arginine, i use again, powder, again, pharmaceutical quality, L Citrulline, just recently introduced.
Research seems to indicate problems with high dose, (diarrhea) i used about 15g, divided.
Stools went from slightly loose, nearly normal, to normal, plus peristalsis, (normal bowel action/muscle) returned, brilliant.
I have always been using fibergel at least twice daily for years, to ensure i never get any stasis in bowel.
The bodies use of amino acids are extremely complex, it appears they are ignored by the British NHS, in my case, i would say, amino acids, especially L Tryptophan, is the answer, look it up, tryptophan and colitis/chrones.
My consultant commented in a letter to my GP," this patient is controlling his Colitis with Tryptophan", as if to suggest he was aware of it's potential!
My experience with Colitis has been horrendous, articles i have read are even worse, my sentiment is everything is about cause and effect, i would suggest the cause of colitis, is the inability to absorb sufficient amino acids, in the case of Tryptophan, an essential one, and difficult to get the body to absorb this, especially once any bowel disease. All this can be done using doing this as a "Complementary supplement", what do you have to loose?
i purchase these on line, tablets much too small a dose, consequently very expensive, powders brilliant value.
Good luck, by the way, i am not medically trained, just trying to be a survivor, and i would say, achieving just that!
There is a cynical view of all this, and i am cynical, being 67, and that is the American pharmaceutical industry, managed once to ban tryptophan, they cannot patent it, basically they do not want us to use such substances, basically, it's part of food/protein, can that be a bad thing?

hi! i have a tireddness feeling and mood problem, therefore i tried to use natural trytophan, but it causes diarrhea.
Is it normal at begining of taking trytophan ?
I take a little amount... max 2-3 g.

But i causes diarher, i tried to lift d vit too, not soo high, but to approx. 8000 NE ...
It is also irritating my stomach/ bovel.
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