C-Diff and UC - can I take both pred and vancomycin together?

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Regular Member

Date Joined Jan 2013
Total Posts : 204
   Posted 8/14/2016 6:40 AM (GMT -6)   
This is the start of Day 4 on Vancomycin 250ml 4 times a day. So far, I can eat a thing and I'm so nauseous and keep reaching as a side-effect.

I'm currently on Infliximab every 8 weeks. Last infusion was 1st July. The doctor's don't put me on steroids for the UC at the same time as Vancomycin so I don't understand how I'm supposed to get better with the UC.

Has anyone been on steroids and van at the same time when treating UC and C-Diff. I am petrified for surgery. I had tried Flagyl 400 3 times a day before this. Started the Vancomycin on Thurs morning.

Regular Member

Date Joined Aug 2015
Total Posts : 20
   Posted 8/14/2016 9:37 AM (GMT -6)   
I have been in your exact position before (and am actually dealing with c diff again right now and back on vanco). When I was first diagnosed with c diff I had already been taking prednisone for a flare. My dr at the time abruptly stopped me on the pred and put me on antibiotic. I questioned it but he said it's not safe to take pred and vanco. Well a week later my entire colon was inflamed to the point where it literally almost burst (seen on CT scan). I was hospitalized for a week and the sickest I had ever been. Obviously stopping the prednisone caused my colitis to go out of control. I got a new dr and he put me on IV steroids while in the hospital and still taking the vanco. It took ten weeks for me to recover, while being on 60mg of prednisone and 250mg vanco 4 times a day, then tapered.

It is risky to do both, but just make sure the dr is treating both c diff and colitis- don't let one get ignored. Just my awful experience :(

Do you think you're responding to the vanco at all? I don't think I am this time around. I've been on it for ten days with no results...I do t think it should take that long. Idk what they're gonna do for me now but I'm more scared than I ever have been with colitis. C diff is so terrible!

I also get infliximab every 8 weeks. You're probably due for another one soon right? Are they still going to do it with your infection? I was scheduled for one of Friday but they canceled it because I'm positive for c diff. Now I'm afraid I'm going to flare along with the c diff too.

sorry this post is so long long! just wanted to share our similar situations. Good luck!

Veteran Member

Date Joined Feb 2014
Total Posts : 2152
   Posted 8/14/2016 2:27 PM (GMT -6)   
Minners..I think the reason they wont give you steriods is that they need to get rid of the C difficil before hand, its just procedure I think. I would really try to start eating something, as taking Vancomycin at such a high dose with an empty stomach is not great for anyone.

ktj...If the second round of antibiotics arent working I would start to look at FMT treatment as that is the best way to treat C Difficil after failing antibiotics twice.

Samantha, 45 yrs
Stopped smoking Jan 2013. Diagnosed Left sided UC, 8th Feb 2014.
Gluten, Dairy, Sulfite, Salicylate, and Histamine intolerant
July... Currently taking Prednisone 50ml

Regular Member

Date Joined Nov 2013
Total Posts : 180
   Posted 8/14/2016 7:24 PM (GMT -6)   
Are the side effects of the c diff treatment that awful? I'm worried I have it. Bringing in a stool sample tomorrow. I'm not sure which is worse, getting c diff from the cipro or having the cipro cause a total blowout of my colitis. This is the worst I've ever felt. My local wedding reception and legal marriage (we had a destination wedding) is in two weeks... Honeymoon in 7. Kind of terrified I'm going to have to cancel everything.
30F Diagnosed Sep '13 w UP.

Previous relief on primal diet.

Currently flaring, on asacol 800mg x 2 twice daily, salofalk enemas nightly.

No long taking : entocort (2 weeks after diagnosis were unsuccessful), salofalk oral, cortifoam.

Veteran Member

Date Joined May 2015
Total Posts : 2236
   Posted 8/14/2016 7:31 PM (GMT -6)   
I was on IV steroids and vanko at the same time for c diff. I was in university of Chicago and they gave them together.
Have you been tested for cmv?
I advise getting remicade levels tested
The nausea can be from flaring, c diff, and meds
Flagyl is not so effective in getting rid of c diff in IBD patients.
Make sure you are cleaning with bleach to prevent reinfecting yourself
21 year old female
Originally diagnosed with severe UC on 4/27/15
Diagnosis switched to Crohn's 6/16
Remicade 10 mg/kg
Imuran 50 mg
Entocort 9mg
zofran as needed

Please excuse typos. Usually post from my phone.

Veteran Member

Date Joined Feb 2011
Total Posts : 4205
   Posted 8/14/2016 8:11 PM (GMT -6)   
The do do both antibiotics and steroids at once. Very often in hospital, and both given IV.

But you don't know if the UC needs pred until the c-diff is treated. You could needlessly take pred. Also, if pred masked any c-diff symptoms, it could be prematurely concluded c-diff was gone.

Also, pred does nothing to stop UC. That is what the Remicade is for.
11/08: ischemic colitis and scope perf colon. 12cm colon/ileocecal resected. IV antib:sepsis.
01/10: Dx: Mod. UC pancolitis. Rx: Lialda 3x.
02/11: Major flare w/antib:sinus. Rx: 40mg Pred taper. 6mp.
07/11: Histol remiss rt/trans; worse sigmoid. Rx: Rowasa & hydrocort
Curr: 1-2 soft-formed stool, no urgency: Lialda 2x, NO PRED, probiotics, Vit-D/C

Veteran Member

Date Joined Oct 2014
Total Posts : 730
   Posted 8/14/2016 8:50 PM (GMT -6)   
I was in same scenario and my former GI doc would not add prednisone even though I knew I was flaring in addition to the cdiff. It was only after I called him on his cell phone telling him about my symptoms while on the toilet that he offered to get me on the schedule the next day for a flex sig. Sure enough, flaring in addition to cdiff. My remicade infusion was moved up, pred was added but I ended up in the hospital because of the nausea. If you can't keep your meds down, you need to call. Unfortunately for us, we have to sometimes be our own advocate for the proper care.

It's true that prednisone shouldn't be added unless you're flaring but it definitely can be done. If you're actively flaring while on remicade, I agree with previous poster to get remicade levels drawn. You won't recover from your flare unless treated. Remicade infusion could be moved up, dose changed, prednisone added, etc. I hope you feel better soon and totally empathize with your state of misery.
43 yo; dx 2001 left sided UC
asacol max dose for several years
prednisone and rowasa when flaring
remicade since 2009; zofran, canasa
Factor V Leiden-blood clots x3
gabapentin, cymbalta for neuropathy in feet most likely from humira. Insurance denied lyrica so now on low dose methadone
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