Ok I have been partially down this road in the past, this is a new angle.
Induction of Intestinal Inflammation in Mouse by Activation of Proteinase-Activated Receptor-2/www.ncbi.nlm.nih.gov/pmc/articles/PMC1850779/
What we have going on here is PAR-2 activation by trypsin and mast cell tryptase which are elevated
in UC. While our alpha-1 antitrypsin is low.
Quercetin is both a mast cell stabilizer/trypsin/tryptase inhibitor.
The problem is you cant get quercetin to the colon unless you I guess overload dosage
with like 50/mg/kg or about
3 grams for a 60 kg person.
But if you take quercitrin it will pass into the colon and breakdown into quercetin.
But you cant get quercitrin as a supplement, except perhaps as dried apple peel will look
at that more. But you can get Rutin which will do the same thing.
Here is the explanation of what is going on,with guercetin,which works in a test tube,but not
in UC models unless you over load to get it to the colon.hera.ugr.es/doi/15772342.pdf
What else is going on of which I will have to track down again if I can find it is that the trypsin
is auto digesting our colon cells,some of the trypsin is also from bacteria .
Will fill out more as I get organized with this info.
Quick points> Summary.
Quercetin is a stronger mast cell stabilizer than cromolyn sodium,go figure.
For upper gut use quercetin, for colon use overload of quercetin like 3 grams a day, or Rutin which
will break down into quercetin in the colon, Rutin will not do much for upper intestine.
Also since quercetin inhibits trypsin, perhaps take after meals are digested.
Another thought might be use both.
Of course quercetin does other things, like lower tnf,correct dysbiosis,kills certain bacteria.
My main focus with this info is to inhibit protease in the colon.
Protective effect of quercetin not seen at lower doses than 50mg/kg in mice.www.omicsonline.org/proceedings/protective-effect-of-quercetin-against-trinitrobenzene-sulphonic-acid-induced-colitis-in-rats-possible-morphological-and-biochemical-alterations-13963.html
might also need high does rutin/www.ncbi.nlm.nih.gov/pubmed/25281414
Just another thought many of the quercetin supplements now have bromalein, don't think this
is a good idea, you want to get the quercetin into the lower gut, not perhaps into the blood stream.
rutin give extended exposure of quercetin in the gut even may help ileitiswww.sciencedirect.com/science/article/pii/S1756464614004204
I see Briggs beat me to it, but he mentions it as an antioxidantthepowerofpoop.com/wp/wp-content/uploads/2015/07/IBD-Briggs-July-21-2015-1-1.pdf
tryptase inhibitor human uc trial/www.ncbi.nlm.nih.gov/pubmed/11876693
par-2 later info/www.ncbi.nlm.nih.gov/pmc/articles/PMC3035886/
PSTI pancreatic trypsin inhibitor lower in UC/www.ncbi.nlm.nih.gov/pmc/articles/PMC1869860/pdf/amjpathol00050-0024.pdf
anti tryptase enemaonlinelibrary.wiley.com/doi/10.1111/j.1365-2036.2006.00053.x/full
mast cells in ibd quercetin will also inhibit histamine release/www.ncbi.nlm.nih.gov/pmc/articles/PMC4724914/
Never heard of this theory,mucosal hyperproliferation
UC people are low in DAO in the colon/www.ncbi.nlm.nih.gov/pubmed/2115242
The term colitis suggests mucosal inflammation as the key event. However, it may be that the disease starts with mucosal hyperproliferation, and inflammation of the impaired mucosa is a succeeding event. Therefore we studied the activity of the intestinal diamine oxidase (DAO) in ulcerative colitis (UC). This enzyme was shown to have a mucosal antiproliferative function. Biopsy specimens of 30 patients having a normal rectosigmoidal mucosa showed a DAO activity of 22.8 nmol/min g. In 12 UC patients the DAO activity was 2.7 nmol/min g (p = 0.01). In 3 patients where UC was in remission the DAO activity was 103, 107 and 208 nmol/min g, indicating an antiproliferative rebound effect. Together with the strongly reduced monoamine oxidase (MAO) activity, the decrease in DAO activity indicates that the large bowel in UC is unable to produce a proliferation terminating substance (probably gamma-aminobutyrate) derived from polyamine metabolism by oxidative deamination (DAO) or by the interconversion pathway (MAO
mast cells tnf mouse ibd important sourcewww.jimmunol.org/content/176/7/4375.full
quercetin has strong anti thrombin activity- you may not get blood clots but might
thin the blood, in UC could be a double edged sword/www.ncbi.nlm.nih.gov/pmc/articles/PMC3939009/
Post Edited (Old Mike) : 10/27/2016 7:01:55 AM (GMT-6)