Now this is quite interesting, never looked into this.
I am not sure of the dosage though is this 1 gram a day or 1034 mg a day or what,
the way they have is written is 1,034g/day. Like 2 pounds or so.
Looking at creatine dosing it is probably 1 gram.
It pays to search a few ways on pubmed, I normally search colitis, but once every few
weeks will search inflammatory bowel, if I just searched colitis would not have found this.
guess I should look into this more
too much or even some can be dangerous -rhabdomyolysiswww.medscape.com/viewarticle/405777
also another caution pulls water into the muscles then causes dehydration
in the rest of the body, need to drink extra
possible paleo diet connection/www.ncbi.nlm.nih.gov/pubmed/26874700
clinical trial-looks like it is important enough to have a small trial/clinicaltrials.gov/ct2/show/NCT02463305
now perhaps I can see how only one gram of extra creatine can tip the balance
The daily Cr requirement for an average 70-kg adult male is approximately 2 g, up to half of which may be derived by intestinal absorption from dietary sources such as meat, fish and other animal products . The remainder is synthesized de novo from arginine, glycine and methionine by a two-step enzymatic reaction, utilizing arginine:glycine aminotransferase (AGAT) to generate guanidinoacetic acid (GAA) predominantly in the kidney, followed by hepatic methylation of GAA via guanidinoacetate methyltransferase (GAMT), using S-adenosylmethionine (SAM) as a methyl donor . Cr biosynthesis accounts for ~70 % of the total utilization of labile methyl groups in the body, with SAM availability governed by levels of folate, vitamin B12, vitamin B2 and one-carbon precursors such as serine, histidine, tryptophan and choline [18, 19]. As such, deficiencies in folic acid and/or vitamin B12 are proposed to undermine GAA methylation and impact Cr biosynthesis . Dietary and endogenous Cr enters systemic circulation and is actively transported into multiple tissue compartments by a transmembrane Na+ and Cl− -dependent creatine transporter (CrT), encoded by the SLC6A8 gene . Approximately 1.5–2.0 % of the total Cr and PCr pool is degraded daily via simple non-enzymatic chemical dehydration to creatinine, which is lost from cells by diffusion and targeted for urinary excretion .
creatine kinase and inflammatory disorders/www.ncbi.nlm.nih.gov/pmc/articles/PMC4987751/
metabolic regulation barrier functionwww.tandfonline.com/doi/full/10.4161/21688362.2014.970936
monohydrate vs hydrochloride
in the first paper the patient was using the hydrochloride/www.kagedmuscle.com/blogs/science/85398979-benefits-of-creatine-hcl
Post Edited (Old Mike) : 1/7/2017 10:21:54 AM (GMT-7)