We do get posters once a month who have trouble swallowing large pills, it's not incredibly rare or anything. Always check with your doctor or pharmacist but this is my understanding.
Mesalamine-based medications have a red/orange delayed release coating, like your lialda. That coating cannot be broken. It is a PH based formula that releases once the large intestine is reached. The instructions say to throw away broken or damaged pills as they cause stomach upset when damaged.
Delzicol comes in a large clear capsule, and inside are smaller red/orange pills. The clear capule can be
opened and really serves no purpose.
Pentasa granules are available in some countries,
open a packet and swallow the red/orange small grains. Pentasa capsules can be
opened and contain orange/red grains. m.cvs.com/webcontent/images/drug/DrugItem_1607.JPGcached.imagescaler.hbpl.co.uk/resize/scaleWidth/620/offlinehbpl.hbpl.co.uk/news/2MM/7E335703-DE1A-6E84-E3CC9AEE226C46BD.jpg
Colazal comes in a colored capsule that can be
opened. The directions say that it can be sprinkled over yogurt or apple sauce and eaten.
Sulfasalazine can be crushed. They aren't mesalamine, but rather a more complex molecule that your gut bacteria cleave into mesalamine and a byproduct once it arrives within the large intestine.
Dipentum® (generic Olsalazine) should be the same process as Sulfasalazine.