That is sort of one of my theories, we have become auto-vaccinated against our own gut bacteria.
The gut bacteria have somehow escaped the control of the gut immune system and are now presented
to the general immune system.
Primary manifestation of Inflammatory Bowel Disease (IBD) following subcutaneous autovaccination.
Onset of inflammatory bowel disease (IBD) is nowadays seen as an interplay or a combination of genetic susceptibility, disturbed intestinal immunity and environmental factors including gut microbiome. However, the initiation of inflammation and progression to IBD pathogenesis in a given individual is poorly understood.In this case report we describe the clinical course of a 17-year old female patient, developing symptoms suggestive of IBD after "autovaccine therapy", in which sterilized samples of the patient's own stool were injected subcutaneously for improvement of her general immunity. The patient presented with a severe onset of disease, which was firstly suspected as ulcerative colitis on outpatient examination and later corrected to IBD with Crohn's- like features in our institution, due to high systemic inflammation, mixed lymphocytic-granulocytic infiltrates in gastric biopsies and further characteristics suggestive of Crohn's disease. A prolonged and complicated course was seen subsequently with intermittent steroid dependency in the long term.Numerous publications postulate that (auto-)immune reactions against resident bacterial stool flora may play a role in IBD. It is possible that in this patient tolerance to endogenous bacteria was disrupted by systemic pro-inflammatory mechanisms induced by autovaccination.