Any idea when it will be an officially approved UC treatment? Still off-label that I know of.
Interesting but that article is from July 28, 2016. The latest news is the Phase 3 trial was posted in NJMA. press.pfizer.com/press-release/phase-3-octave-studies-oral-tofacitinib-ulcerative-colitis-results-published-new-englawww.nejm.org/doi/full/10.1056/NEJMoa1606910
The OCTAVE Sustain study evaluated the efficacy of tofacitinib as maintenance therapy compared to placebo in adult patients with moderate to severe UC. It included patients who had completed one of the OCTAVE Induction studies and had achieved at least clinical response
In OCTAVE Sustain, 34.3% and 40.6% of patients achieved remission at Week 52 with tofacitinib 5 mg BID and tofacitinib 10 mg BID, respectively, compared to 11.1% taking placebo