Neurotoxicity with Glutamine supplementation

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xy123
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Date Joined Feb 2014
Total Posts : 678
   Posted 9/30/2017 7:08 AM (GMT -7)   
Many of us know that L-glutamine has been used as an additional tool to treat IBD. (Just google "glutamine crohn's colitis pubmed" to see some of the papers)

Although This new Cochrane review says:
review said...
Currently there is insufficient evidence to allow firm conclusions regarding the efficacy and safety of glutamine for induction of remission in Crohn's disease. Data from two small studies suggest that glutamine supplementation may not be beneficial in active Crohn's disease but these results need to be interpreted with caution as they are based on small numbers of patients. This review highlights the need for adequately powered randomised controlled trials to investigate the efficacy and safety of glutamine for induction of remission in Crohn's disease.


Anyways...

I bought l-glutamine supplements to try it out; but then I've found some links between glutamine and neurotoxicity:

onlinelibrary.wiley.com/doi/10.1002/hep.21357/pdf
forums.phoenixrising.me/index.php?threads/glutamine-is-harmful-relationship-with-ammonia-and-astrocytes.38680/
/www.ncbi.nlm.nih.gov/pmc/articles/PMC4714775/
/www.ncbi.nlm.nih.gov/pubmed/11754523

/www.ncbi.nlm.nih.gov/pubmed/2566647

What do you guys think?

OM, do you think it is safe to supplement with L-Glutamine?
The dosage used to treat IBD is generally higher (around 30 grams/day) than the doses used for the purpose of physical training and muscle gaining etc...

Thanks.

Edit: This is the new Cochrane review: onlinelibrary.wiley.com/wol1/doi/10.1002/14651858.CD007348.pub2/abstract

Post Edited (xy123) : 9/30/2017 8:17:13 AM (GMT-6)


IamCurious
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Date Joined Jan 2010
Total Posts : 3073
   Posted 9/30/2017 1:13 PM (GMT -7)   
I have heard from more than one source that taken with food glutamine is great for bodybuilders because it helps to build muscle. But taken on an empty stomach glutamine helps repair intestinal tissue.

According to Dr. Robert Atkins, the Atkins diet guru, not only is glutamine effective for healing the digestive tract, (which is what IBDers like us need), but that it also snuffs out cravings for sugar.

On page 168 in his book, 'Dr. Atkins' Vita-Nutrient Solution', he talks how glutamine "maintains the structural integrity of the intestines to such an extent that it is dubbed 'intestinal permeability factor.' No other nutrient is as important for gastrointestinal integrity."

But I stopped taking it after more recent studies such as what you listed above show that daily glutamine intake can be problematic. But after my most recent flare I found that taking some glutamine seemed to speed up recovery. That is why my signature says I take glutamine only when I feel gut repair is needed after a flare, not regularly at all.
Male, born 1951, DX IBD Feb08. No meds, allergic to Mesalamine. Food diary instead of SCD or Paleo.
When needed VSL#3DS sprinkled over powdered psyllium seed is very helpful.

Lactobacillus Reuteri (NCIMB 30242), Culturelle, Saccharomyces boulardii.
Fish oil, curcumin, extra D3, magnesium, multivitamin, glutamine when gut repair needed.

Resistant Starch and lots of fruit & vegetables (but no cruciferous), No Gluten, no soda, no HFCS, no xylitol or sorbitol, no trans fat, no shellfish, no carrageenan, no GMO foods saturated with Roundup.
Nature created all of the locks, therefore Nature has all of the keys

xy123
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Date Joined Feb 2014
Total Posts : 678
   Posted 10/2/2017 4:22 AM (GMT -7)   
IamCurious said...

But I stopped taking it after more recent studies such as what you listed above show that daily glutamine intake can be problematic. But after my most recent flare I found that taking some glutamine seemed to speed up recovery. That is why my signature says I take glutamine only when I feel gut repair is needed after a flare, not regularly at all.


@IamCurious, I agree with you. You can also try drinking bone broth soup (especially at those hard times) because it is very helpful at healing the intestines.

--/--

Old Mike, are you there?
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