Naltrexone questions.

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Regular Member

Date Joined Apr 2016
Total Posts : 80
   Posted 10/5/2017 10:42 AM (GMT -7)   
Hi, I'm wondering about LDN. I did some googling on the matter and am currently working my way to obtain some and try the method(it seems to be hard to get in my country, which is Turkey) but I am wondering; how is it being received by the science people? Are there any trials to determine whether it works or not on autoimmune diseases or is it in any way close to being regarded as a legitimate way to cure these diseases? Can we establish a success rate based on the success stories of people? If we can, how is it, compared to biologics, immunomodulators and standard mesalamine medications?

By the way, if I can obtain some, I know I must start with 0.5-1 mg dosage and increase slowly but is the consumption method important? Can I just add it to water or should I take as capsules or something to make it go all way to the intestines without being broken down by the enzymes? And lastly, for how long should I take it before expecting any results or saying that it failed for me?

Veteran Member

Date Joined Jan 2010
Total Posts : 3072
   Posted 10/5/2017 1:37 PM (GMT -7)   
There are many threads discussing LDN such as the first thread here. BeeSting's post in that thread is especially helpful. My post in that thread can help answer your question why LDN isn't fully accepted by the mainstream.

The 2nd thread is from UC Resources and contains a lot of information. Skip's Pharmacy ships all over the world, maybe even to Turkey.
Male, born 1951, DX IBD Feb08. No meds, allergic to Mesalamine. Food diary instead of SCD or Paleo.
When needed VSL#3DS sprinkled over powdered psyllium seed is very helpful.

Lactobacillus Reuteri (NCIMB 30242), Culturelle, Saccharomyces boulardii.
Fish oil, curcumin, extra D3, magnesium, multivitamin, glutamine when gut repair needed.

Resistant Starch and lots of fruit & vegetables (but no cruciferous), No Gluten, no soda, no HFCS, no xylitol or sorbitol, no trans fat, no shellfish, no carrageenan, no GMO foods saturated with Roundup.
Nature created all of the locks, therefore Nature has all of the keys

Regular Member

Date Joined Jul 2016
Total Posts : 362
   Posted 10/5/2017 1:39 PM (GMT -7)   
I've been on LDN since January 2017, and it has been amazing. I'm flaring now because I had an underlying infection I didn't know about, which is something LDN can't stop. After my last flare I recovered but I still didn't feel right. Within two weeks of taking LDN I went from a 6/10 in wellness to 9/10. Had way more energy, my little bit of remaining inflammation stopped, I started gaining weight -- it was pretty great. Because I'm on morphine for my current flare I've had to stop LDN (they have opposite actions). But once I'm on antibiotics for my MAP infection and my flare calms down, I'm getting back on LDN ASAP. I find it to be a miracle drug.

The mainstream medical community does not really know about it. There's an independent organization called the LDN Research Trust that is conducting trials to provide evidence for the efficacy of off label use. If you just Google search LDN there are lots of research papers on there. There's also the Facebook group "IBD and LDN" where you can get advice specific to IBD.

I don't know the exact statistics, but I would arrange LDN patients into these groupings: most get some improvement but it's not total, followed by some acheiving total remission, followed by some having no improvement, followed by a minority who actually get worse. I can't attest to the success rate vs. biologics but my guess is that it would be more. It seems that people who use multiple therapies with LDN get better results.

I know the exact mechanism of how LDN works, scientifically, if you want me to just write it out here.

You need to find a compounding pharmacy who will make it, and it needs to have an avicel (microcrystalline cellulose) filler. There is much debate over what kind of filler works best for absorption. Some people are so against filler they insist on getting LDN in liquid form. The reason for compounding is that Naltrexone is normally used at higher doses of 50mg and doesn't come in the LDN form, so a pharmacist has to make it.

Finding a doctor who is open minded enough to let you try it is always a challenge. Most are totally ignorant and choose to stay that way even if you offer them clinical evidence. I personally would not order it online but some people do because they are so desperate to try it.

Yes, you start with a low dose and work your way up. I started at 1.5mg and found it tolerable. My sweet spot is 3mg. Each person's sweet spot is different... it varies from as low as 0.1mg-4.5mg. Generally the LDN effect is lost if you go above 4.5mg. For me, 4.5 is too much -- too many side effects, like not being able to sleep at night and feeling run down during the day. More is not necessarily better! Some people can't up their dose as quickly as I did. They go up by 0.5mg at a time.

As for consumption method... the best way is on an empty stomach before bedtime. You need to take it between 11pm-2am to maximize its effect. I can explain why if you want. No, you don't mix it with water.

The results take time. My bowel mucosa took 6 months to totally heal, but my fatigue, cramping, blood and mucous, succeptibility to colds and infections, general weakness and failure to thrive -- they all went away within 2 weeks. By 6 months I was eating foods I haven't eaten in years. A lot of LDN users with IBD say that after 1-2 years they can even eat gluten again, though most choose not to. I would say for initial results you should wait 3-6 months. If you get intolerable side effects (like sleeplessness) that don't go away with dosage adjustment, then LDN might not be for you.

The results depend on the severity of your condition, and what your immune system is doing. LDN tweaks the immune system in a very specific way and if that specific way is not your problem then LDN won't help you. But if you're lucky, LDN will be like a lock-and-key for your body and you'll get great results. I recommend joining that Facebook group if you have FB.

Post Edited (Connor77) : 10/5/2017 2:45:04 PM (GMT-6)

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