High wbc and crp

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Hoda
Regular Member


Date Joined Jun 2017
Total Posts : 24
   Posted 10/5/2017 12:34 PM (GMT -7)   
Hello,

I'm on my 12th week of prednisone (steroids) started with 40 mg and tapered to 5 mg (1 pill ). Before i started the steroids my crp and wbc were high. Then a month after steroids they became normal. Now i have 1 week left of steroids and i got a blood test done yesterday and the results are high wbc and high crp again. Does that mean im relapsing again? Or that the steroids didnt work or that the doctor is going to increase them?
I'm super scared about this blood test result why did the wbc and crp increase after such a strong treatment ?? What should i do and not do please sad
Ulcerative colitis since 2014 (proctitis and gastritis)
Colonoscopy 2015 showed mild proctits
Colonoscopy 2017 showed severe proctitis and ulceration
Asacol 1600 mg 3 times a day
Imuran 150 mg 1 time a day
Predinsilone 2nd course
Calcium / Zantac / Multivitamins
Enemas and pentasa suppository daily
Vitamin b12 injections monthly

blksteeda
Veteran Member


Date Joined Dec 2009
Total Posts : 1632
   Posted 10/5/2017 1:05 PM (GMT -7)   
Chances are the steroids were keeping things under control as a maintenance drug. As you reduced the mg, the issue started to creep back in. I had that issue a lot while on prednisone. As soon as I got less than 20mg, everything started to flare back up again.
43 Male, South Florida

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FlowersGal
Regular Member


Date Joined Feb 2017
Total Posts : 415
   Posted 10/5/2017 1:15 PM (GMT -7)   
Same here -- I was dependent on prednisone to keep my disease under control. Now I'm on Entyvio infusions and finally prednisone free.
UC pancolitis DX March 2016, Partial Colectomy for diverticulitis Sept 2014
Apriso .375 g x 4/day, Canasa & Uceris foam as needed
Supplements: Zinc, L-glutamine, Probiotics: Reuteri pearls, VSL #3, Folic Acid, CoQ10, turmeric, boswellia, milk thistle, NAC, reservatol, colostrum, glycine
Started Entyvio 3/29/17 (Constant flares since March 2016 only relieved by Prednisone)

Hoda
Regular Member


Date Joined Jun 2017
Total Posts : 24
   Posted 10/5/2017 11:52 PM (GMT -7)   
That's not so good news sad
Biksteeda what did the doctor do whenever u dropped less than 20 mg and relapsed ?
Ulcerative colitis since 2014 (proctitis and gastritis)
Colonoscopy 2015 showed mild proctits
Colonoscopy 2017 showed severe proctitis and ulceration
Asacol 1600 mg 3 times a day
Imuran 150 mg 1 time a day
Predinsilone 2nd course
Calcium / Zantac / Multivitamins
Enemas and pentasa suppository daily
Vitamin b12 injections monthly

blksteeda
Veteran Member


Date Joined Dec 2009
Total Posts : 1632
   Posted 10/6/2017 4:26 AM (GMT -7)   
Hoda said...
That's not so good news sad
Biksteeda what did the doctor do whenever u dropped less than 20 mg and relapsed ?


I was always kept at 20mg or higher if things got worse. Prednisone was the last drug to fail me and opted for surgery.

Connor77
Regular Member


Date Joined Jul 2016
Total Posts : 362
   Posted 10/6/2017 11:33 AM (GMT -7)   
WBC goes up when inflammation goes up because WBC are involved in creating inflammation in the body. It's part of the vicious cycle of our disease. You get a bit of inflammation, then WBC show up to investigate, they feel there's a problem, so they signal for more inflammation.

If your CRP and WBC are rising again then you're unfortunately relapsing. You probably needed to stay on prednisone for a while longer, or you need a different medication altogether.

What you can try doing is increasing your prednisone dose incrementally. Add 5-10mg and see if the CRP/WBC counts go down. No need to go back up to 40mg if you don't have to. But if you really start to flare full on, you probably have to!

20mg is minimum to have any impact on a flare.

Hoda
Regular Member


Date Joined Jun 2017
Total Posts : 24
   Posted 10/6/2017 11:00 PM (GMT -7)   
Thanks connor77 for your explanation. I hope i don't need to go back up to 40 mg. This time the skde effects have been treating me bad.
Ulcerative colitis since 2014 (proctitis and gastritis)
Colonoscopy 2015 showed mild proctits
Colonoscopy 2017 showed severe proctitis and ulceration
Asacol 1600 mg 3 times a day
Imuran 150 mg 1 time a day
Predinsilone 2nd course
Calcium / Zantac / Multivitamins
Enemas and pentasa suppository daily
Vitamin b12 injections monthly
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