What does low SIgA mean?

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Date Joined Sep 2016
Total Posts : 126
   Posted 10/5/2017 1:56 PM (GMT -7)   
My naturopath ordered some comprehensive blood and stool tests, and the results came in today. Looks like there is low vitamin D, candida overgrowth and low SIgA. I am familiar with what low vitamin D and candida mean – pretty typical for UC patients, but SIgA is a mystery to me. From a google search I gather that it prevents the immune system from having an appropriate response to intestinal bacteria. Does anyone have a better explanation? Is this a significant indicator? What can be done about it?
Diagnosed in 2010 - moderate pancolitis
2 year remission since 2014
September 4, 2016 - flare begins, 6 or more bms per day, 40 mg prednisone, hydrocortisone suppositories (stopped Nov. 9)
Scope November 9 showed mild, distal UC.
Current medication: nightly Rowasa, nortrypteline 10 mg from ibs, Baswellia, Turmeric, multivitamin, TCM herbs, acupuncture

Canada Mark
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Date Joined Jan 2013
Total Posts : 3481
   Posted 10/5/2017 7:13 PM (GMT -7)   
sIgA - means Secratory IgA. It is an antibody. See geeky stuff below. It's 'secreted' by immune cells in your intestines and other areas - hence the term secretary before it. Your body is extremely busy secreting these molecules every day.

No offence towards your naturopath, but I highly doubt there is going to be an issue with sIgA in your body. There is only a small amount in your blood anyway <-- well small in relation to other antibodies. However in your intestines it is a whole other story. Again, see geeky stuff below smile

Geeky stuff:

Even just in our intestines alone; simply to protect us from oral antigens (bacteria etc) that we swallow on our food or breathe in and swallow in our mucus/spit we have about 2x10^10 or 20,000,000,000 cells (so multi billions of B-cells) that secrete IgA (antibody) or "flags". And every single day these B-cells secrete between 5 and 15 grams of secretory IgA in our mucus. So that's ~6 x10^23 IgA molecules per gram.... so the amount of sIgA were secrete daily in our intestines alone to protect us from what we eat, swallow, and what reside within us is an amount or number that is so high and so large it's hard to even count or grasp...

Math wise it's this ( I think it's correct) but a math person might want to double check as I hate math:

So every single day in our intestines we secrete 600,000,000,000,000,000,000,000 molecules of secretory IgA per gram x (times) between 5-15 grams secreted each day.

Multiply the above number by 15 (for 15 grams) and this tells us the cells of our intestines alone, every single day secrete up to 9,000,000,000,000,000,000,000,000 secretory IgA molecules simply to protect us from the bacteria in and entering our guts...

That's crazy.

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Date Joined Mar 2007
Total Posts : 1653
   Posted 10/5/2017 9:29 PM (GMT -7)   
When one Google's "low SIgA," the first page of results is all blogs from naturopaths or sites trying to sell something or sites full of pseudoscience. Very telling, if you ask me.

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Date Joined Dec 2008
Total Posts : 15404
   Posted 10/5/2017 10:45 PM (GMT -7)   
beave said...
When one Google's "low SIgA," the first page of results is all blogs from naturopaths or sites trying to sell something or sites full of pseudoscience. Very telling, if you ask me.

I saw the same thing so I didn't say anything for fear of coming off as negative. turn
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