I noticed improvements from things that work vasoconstrictive on the colon like smoking too. As well as doing sports, which seems to help by drawing blood from the intestines to the muscles.
I think to live with UC you are best with being a slow metabolizer. Thats why older people with probably other problems additional to UC, that lead to adapted lower metabolism, do have less problems.
Less blood supply in the colon = lower metabolism?
When you are in remission, with inadequate blood supply, maybe there is too little waste removal.
But once your body tries to increase it, you get back into inflammation & the increasing metabolism circle.
So you basically prevent your body from 'healing' itself by taking medication. But because of other reasons this healing does not work as efficient so medication is needed unless the other reasons are solved.
Butyrate as a SCFA does work on several ways. I tried palmitic acid before butyrate and as I thought, it worked only by increasing metabolism. And I got into a flare. 2 weeks. But after 2 days with supplemental cysteine and 30g of inuline, my flare was gone and stool was perfect.
Palmitic acid and butyrate both work as a energy source but butyrate got some more interesting tasks for UC that palmitic acid does not do. Like supressing autophagy, gut barrier, inhibition of nfKB, regulation of IL-1b, TNF-α, IL-2, IL-6, IL-8, IL-12, iNOS, COX-2 .
"The data presented above demonstrate that butyrate maintains energy homeostasis and prevents autophagy by acting as an energy source rather than as an HDAC inhibitor. To provide additional support for this mechanism, we performed mitotracker experiments with three molecules with defined actions similar to butyrate. Propionate is a SCFA that enters the TCA cycle through succinyl-CoA to function as an energy source and an HDAC inhibitor (Hinnebusch et al., 2002 ; Waldecker et al., 2008). In contrast, palmitate is a long-chain fatty acid (LCFA) that enters the TCA cycle as acetyl-CoA and only functions as an energy source, whereas trichostatin A (TSA) only functions as an HDAC inhibitor."
Supplementing with Butyrate or butyrate producing bacteria is one thing.
But as with all probiotics, its not only about
the bacteria itself. Its what they produce.
I read several articles about
supplementing butyrate or bifidobacteria. Both worked kind of well.
But supplementing the "end product" or supplementing the producers is missing one big thing. Imo.
Bacteria without proper feeding will be gone after some time & with still increasing or high amounts of "bad bacteria / h2o2" that destroy them.
So maybe supplementing with bifidobacteria, prauznitzii or roseburia can help as a starter kit.
And enemas or supplementing with Butyrate can help immediately.
But over the long run, you need to establish a good balance and homeostasis that can produce butyrate and keep itself alive.
Biggest problem in my opinion is to get into this healty homeostasis. Once you are in it, I think its pretty much self supporting. Its harder to get out.
Post Edited (MRFISH) : 11/25/2017 3:51:31 AM (GMT-7)