Can Uceris or Lialda actually cause loose stools?

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Regular Member

Date Joined Oct 2017
Total Posts : 27
   Posted 11/4/2017 8:27 AM (GMT -6)   
Before my recent diagnosis, I had only slightly loose stools and many other symptoms. Now I’m about 6 weeks into my medications and all of my symptoms are gone (cramping, bleeding, urgency), but my stools are softer than ever once a day or once every couple of days. Complete mush. Possible side effect of meds??

Veteran Member

Date Joined Jun 2013
Total Posts : 1937
   Posted 11/4/2017 10:04 AM (GMT -6)   
More likely from the flare itself. I find that the last thing Togo back to normal is stool firmness.
42 yrs old diagnosed with proctosigmoiditis 6/13/13
meds- 2 Lialda + sfRowasa every other night- supplements: probiotics (1 VSL3 cap, 1 culturelle and 1 reuteri) 1 gram krill Oil, 1TBSP p. seed powder, 2 g curcumin. Allegra for seasonal allergies as needed. Allergic to sulfites. Currently gluten/dairy free (except yogurt) and eating lots of RS.

Elite Member

Date Joined May 2003
Total Posts : 30216
   Posted 11/4/2017 12:12 PM (GMT -6)   
Can......but misunderstood that some of us are undermedicated or actually overmedicated based on initial tolerance, only on oral or rectal without full coverage of 5ASA meds.

The flare is the fact....and inflammation increase and healing based on how much and location are more complicated regarding stool consistency. Add food into the mix, which can change consistency and increase or decrease.....

Try not to focus on the singular issues. With will start to understand the whole process.

Are you on rectal meds?

*Heather* I give suggestions, do with them what you will.
Status: ...Asacol 3 @ 2x daily; Salofalk enema @ 3rd night (nightly/ flares, tapered/maintenance)
~diagnosed January 1989 UC (proctosigmoiditis)
~Bentylol 20mg as needed; Zantac 150mg; Pulmicort/Airomir (asthma); Effexor XR 75mg (depression); Rosuvastatin 10mg (cholesterol); Telemesartin 80mg / Amlodipine 5mg (BP)
~vitamins/minerals/supplements; Probiotics....(RenewLife Ultimate Flora Critical Care + Genuine Health Advanced Gut Health 15 billion @ bedtime)
~Metamucil capsules 6 @ 2x daily with meals; Vitamin D 4500 IU
~URSO 500mg @ 2x daily for Primary Biliary Cholangitis
"TREAT (FROM)BOTH ENDS" worth it !!

Regular Member

Date Joined Oct 2017
Total Posts : 27
   Posted 11/4/2017 1:56 PM (GMT -6)   
I’m not on rectal meds. Currently feeling great, just really really soft stools. Softer than when I actually felt like I was flaring.

Forum Moderator

Date Joined Aug 2012
Total Posts : 11798
   Posted 11/4/2017 5:09 PM (GMT -6)   
With uc, our days of perfectly predictable, and consistent poop logs are over lol. Even in a remission, my bms bounce around in fimness from solid to slightly soft. Consistency varies a lot with uc, it's perfectly normal, and nothing at all to worry about.

Ypu can take a fiber supplement like metamucil to firm things up and have greater consistency.
Moderator Ulcerative Colitis
, 39, UC Proctosigmoiditis
Rx: Remicade @5mgs/kg/6wks; daily 75mgs 6MP, 4.8g generic-Lialda, and rowasa

Urgency Roused "Oh the places I've pooed from culverts to shady bathrooms" the memoirs of a UC patient. Run, don't walk, to you local bookstore...

Regular Member

Date Joined Jan 2017
Total Posts : 45
   Posted 11/10/2017 12:14 PM (GMT -6)   
Hi there!

Its so hard to say what the loose stools are coming from.

For me, I DO feel like my Delzicol(mesalamine) MAY cause somewhat looser stools. I also know that my UC also causes looser stools I have to be realistic when thinking I figured something out, that maybe I could be wrong.
That said, when I reduced my dosage from the higher 'remission' dose to the lower 'maintenance' dose my stools firmed up for a little while. Another thing I often have to consider it that with more inflammation is more swelling in my colon, and the beginning of a mini-flare can also involve some beautiful solid stools because things are slowing down, and therefore drying out for mechanical reasons. And that may well have been the case when I reduced my dose, too.

I think what I (and some of the others here) are trying to say, is that the likelihood its the UC is higher than if it possibly being the medication. But diarrhea and loose stool ARE on the list of mesalamine side effects, and in my experience it seems like for sure it can.

I've found it most beneficial to gauge my progress on more of a month by month basis rather than day to day. My meds took a long time to really kick in, and almost a year later, I still feel like I'm progressing and feeling better each month. At the same time though, I realize by body just functions differently, and probably if its not one thing its another with this disease. I don't expect to ever be be completely free from its effects. I'd take loose stools every day if that was the only complaint. (even if it was caused by meds lol)
29yo f
Dx Jan '17, mod left side UC with severe joint flares
Meds: Delzicol 2.4mg/d
Supp: multi-vit, turmeric/curcumin, boswellia helps most w/ joints, triphala, mj
Diet: yogurt, grains are a problem. definite coffee addict
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