All of the medications you mention deliver anti-inflammatory mesalamine to the large intestine but how it's delivered varies.
Generic Balsalazide Disodium (brand name Colazal) and generic Sulfasalazine (brand name Azulfidine) are an older class of UC medications, therefore are true generics at a reasonable cost. Unlike Lialda/Asacol hd, there is no red/orange chemical coating with PH-delayed-release delivery. Rather, they are more complex molecules that gut bacterium breaks down into mesalamine and a byproduct. It's the same result but achieved through different means. In the case of sulfasalazine, that unused byproduct is sulfa which is an allergen to some and can cause headaches and number of other side effects, but it is the cheapest by far of all UC meds (about
$75 a month if you pay entirely out of pocket). The majority don't experience side effects of sulfasalazine, you cold always try it and if you get headaches then switch. Overall Balsalazide is a safer bet as the byproduct does not appear to have the same adverse reactions, it's a little more expensive ($200-400 a month if paid entirely out of pocket). Both are tablets taken multiple times a day. There's a lot more interest in these lately due to prescript
ion med pricing. A number of posters use Balsalazide, and some use sulfasalazine. Balsalazide Disodium
of Colazal, comes in 750mg pills, a typical dose is 6,750mgs or 9 pills daily.Sulfasalazine
is a generic
, comes in 500mg pills, a typical dose is 4,000mgs or 8 pills daily.
Lialda is similar to asacol hd, but larger pills: 1,200mg instead of 800mgs. Lialda is taken all at once in the morning, which is it's biggest difference. Lialda has a generic that's new to market but at $1,200 a month it's a rather expensive generic.
Moderator Ulcerative Colitis
John, 39, UC Proctosigmoiditis
Rx: Remicade @5mgs/kg/6wks; daily 75mgs 6MP, 4.8g generic-Lialda, and rowasaUrgency Roused "Oh the places I've pooed from culverts to shady bathrooms" the memoirs of a UC patient. Run, don't walk, to you local bookstore...
Post Edited (iPoop) : 11/7/2017 6:29:21 AM (GMT-7)