I definitely still had cdiff when I started the Humira. I was in the hospital for 9 days and started the Humira on day 8, the day before I was discharged. When I was discharged from the hospital, I continued taking another 2 weeks worth of antiobitoics for the cdiff (flagyl 3x per day and vancomycin 4x per day), and 40 mg prednisone, which I tapered 5mg every 5 days.
They debated whether or not to give me the Humira before they knew the cdiff was gone, but I wasn’t getting any better after being on IV antibiotics for 7 days, so they decided they had to treat the UC and the cdiff simultaneously. Before I took the Humira, I was really sick. I was going to the bathroom more than 15 times in a 24 hours period. It was straight liquid D, blood, stomach pain/cramping, and severe stomach and colon cramping and spasms while I was going to the bathroom. I honestly thought I was dying.
I would say within a day or two of the loading doses, I started to see small improvement. I wasn’t going to the bathroom as often, but it was still liquid D. The Blood went away a few days after that. The pain went away almost immediately.
I’ve been seeing steady improvement since then. I was able to taper the prednisone with no issues at all. I’m praying the cdiff is gone for good since I finished the antibiotics in early October after a 24 day course and haven’t had any issues since then. I’m now at almost 8 weeks on Humira and I feel really good. For the last 3-4 days I’ve only gone to the bathroom twice within the first hour of waking up. The rest of the day has been very uneventful and I am so grateful! No pain, very slight urgency with the second BM in the morning, no blood. My BM still aren’t completely solid. They’re not D, but they’re not back to my old normal yet, but I finally feel like I’m on the right track.
I really wish I had gone on Humira sooner. I think I probably could have avoided cdiff and how incredibly sick I got had I not been mildly flaring for over a year. I kept hoping that things would get better. That the flare would somehow end on its own and the lialda I was taking would somehow be enough. I don’t have any regrets at all about
going on the Humira. I feel better now than I have in a long time, and I really think I’m going to continue to improve from here.
Definitely ask the doctor about
a second cdiff test just to confirm that you don’t have it. If you do have it, get back on antibiotics and ask your doctor how soon he recommends starting the Humira. They prefer you to not have an active infection when starting, but I’m sure it will be considered if the situation warrants it.
I don’t feel that the Humira effected my ability to fight the infection. It took forever to get rid of, but it seemed to be a pretty severe infection from the beginning. I didn’t see any setbacks as a result of starting Humira.
Let me know if you have any more questions. I’m more than happy to help. I really hope you get this under control soon and start to feel better