Prednisone and menstrual cycle

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Shelly1978
Regular Member


Date Joined Jan 2017
Total Posts : 60
   Posted 12/6/2017 9:52 AM (GMT -7)   
one for the ladies

I was using predfoam enemas for a flare and had a period that was barely noticeable . I asked my ibd nurse who said it wasn't caused by the enemas . I was then put on oral pred starting at 40mg . I've now tapered down to 25mg and I have a similar period again. Could it be down to the pred ? I know I shouldn't complain about it being so light but I'm used to them being fairly heavy .
Diagnosed with proctitis Nov 16 using asacol suppositories
Told I don't have proctitis April 17 taken off asacol
Diagnosed with proctitis September 17 using pentasa enema
Flare October 17 - pred foam enemas
November 17 taken off pred foam
Now using prednisone 40mg for one week then tapering
Salofalk granules 3g
Pentasa enemas
20/11/17
Taken off pentasa enema now on suppositories

Crispix
Regular Member


Date Joined Apr 2016
Total Posts : 27
   Posted 12/6/2017 2:25 PM (GMT -7)   
I didn’t have that exact issue, but I do think that prednisone effected my cycle. The period I had right after I finished the prednisone taper was 15 days after my last period. I have shirt cycles, usually about 21-22 days, but 15 is definitely not normal for me. The flow was pretty much the same as it usually is, but I’m sure the steroids had something to do with my period coming so early. I’m usually pretty regular.

Shelly1978
Regular Member


Date Joined Jan 2017
Total Posts : 60
   Posted 12/7/2017 1:16 AM (GMT -7)   
Thank you . It seems there's definitely a connection.
Diagnosed with proctitis Nov 16 using asacol suppositories
Told I don't have proctitis April 17 taken off asacol
Diagnosed with proctitis September 17 using pentasa enema
Flare October 17 - pred foam enemas
November 17 taken off pred foam
Now using prednisone 40mg for one week then tapering
Salofalk granules 3g
Pentasa enemas
20/11/17
Taken off pentasa enema now on suppositories

iPoop
Forum Moderator


Date Joined Aug 2012
Total Posts : 11047
   Posted 12/7/2017 7:13 AM (GMT -7)   
I did some searching and came up with a lot of sources saying, stuff similar to the following.

"If you are using steroids in high dosages, you could have problems related to your menstrual cycle. This drug can interfere with your period and cause you to have irregular periods, especially after prolonged use. Aside from the irregularity in your menstrual cycle, you might not have a period at all. In addition, some women experience heavy bleeding, severe abdominal cramps, upset stomach, and more while using the drug."

Prednisone is a synthetic version of Cortisol, which is a natural hormone in your body. You're basically flooding your body with higher levels of cortisol than your body could naturally produce. Hormones can mess with other processes in the body, here is an example I saw stated a few times:

"Stress activates a hormonal pathway in the body called the hypothalamic-pituitary-adrenal (HPA) axis (10). Activation of HPA axis is associated with increased levels of cortisol and corticotropin-releasing hormone (CRH) (2, 10, 11). The HPA axis, cortisol, and CRH help control stress response in the body. CRH and cortisol release can suppress normal levels of reproductive hormones, potentially leading to abnormal ovulation, anovulation (i.e. no ovulation), or amenorrhea (i.e. absence of menstruation) (10–12). "

Sounds like prednisone can mess with your natural cycle in all sorts of ways..

Shelly1978
Regular Member


Date Joined Jan 2017
Total Posts : 60
   Posted 12/7/2017 7:23 AM (GMT -7)   
Thank you for that . Looks like the steroids could be a cause of it and hopefully when I get off them things should return to normal .
Diagnosed with proctitis Nov 16 using asacol suppositories
Told I don't have proctitis April 17 taken off asacol
Diagnosed with proctitis September 17 using pentasa enema
Flare October 17 - pred foam enemas
November 17 taken off pred foam
Now using prednisone 40mg for one week then tapering
Salofalk granules 3g
Pentasa enemas
20/11/17
Taken off pentasa enema now on suppositories

momto2boys
Veteran Member


Date Joined Jun 2013
Total Posts : 1866
   Posted 12/7/2017 7:24 AM (GMT -7)   
Pred and even cortenemas really messed with my cycle. I had strange periods while I was on them. Irregular cycle lengths, some with heavy bleeding and others with barely anything at all.
42 yrs old diagnosed with proctosigmoiditis 6/13/13
meds- 2 Lialda + sfRowasa every other night- supplements: probiotics (1 VSL3 cap, 1 culturelle and 1 reuteri) 1 gram krill Oil, 1TBSP p. seed powder, 2 g curcumin. Allegra for seasonal allergies as needed. Allergic to sulfites. Currently gluten/dairy free (except yogurt) and eating lots of RS.
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