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Dani001
New Member


Date Joined Dec 2017
Total Posts : 2
   Posted 12/7/2017 1:38 PM (GMT -7)   
Hi All,
I was recently diagnosed with UC- pancolitis Oct 29 this year at age 32 after a three day stint in the hospital. The good news is that I have responded extremely well to the prednisone and am almost tapered off. I just started oral mesalamine last week (3 800mg pills 2x day).

I also suffer from migraines. While I do take a daily preventative and have an abortive, sometimes if I don't catch it quick enough I need to take an OTC. The ONLY thing that really works for me is Naproxen Sodium (Aleve). My hospitalist and my GI doc both told me people with UC should stay away from NSAIDs, especially now that I'm on mesalamine.

Has anyone had any experience or insight on this and why NSAIDs are bad for folks with UC?
Thanks!
Dani

notsosicklygirl
Forum Moderator


Date Joined Dec 2008
Total Posts : 15427
   Posted 12/7/2017 1:56 PM (GMT -7)   
What do you take as a preventative? I took pristiq for a while and it totally wiped out my migraines. I've also done well with various birth control, ones that don't have "off" pills.
Co-moderator: Ulcerative Colitis
Currently: no meds. 6/15 Step One J-pouch Surgery Complete! 9/15 Step Two Complete! 11/15 Step 3 Complete!

Give a man a fish and he will eat for a day; teach a man to fish and he will eat for a lifetime; give a man religion and he will die praying for a fish.

Dani001
New Member


Date Joined Dec 2017
Total Posts : 2
   Posted 12/7/2017 2:03 PM (GMT -7)   
Hi notsosicklygirl- I take nortiptaline (also has done wonders for my TMJ) and JUST switched from imitrex to maxalt to see if that will help. My migraines are hormone-related, so I skip the placebo birth control pills which has helped to reduce the number I get.

iPoop
Forum Moderator


Date Joined Aug 2012
Total Posts : 11046
   Posted 12/7/2017 2:09 PM (GMT -7)   
Welcome to the forum. It's generally advisable for us not to take NSAIDs when other solutions work well. Do some of us occasionally and temporarily use NSAIDs due to headaches or other things? Oh, yes, absolutely!

The main factor limiting NSAIDS use is the concern for the development of gastrointestinal toxicity including mucosal injury. A possible association between the use of NSAIDS and the onset or relapse of IBD has been repeatedly suggested.

Here's some reading on it. The jury is still out on whether newer COX2-only inhibitors are safer than old-school NSAIDs like aspirin that block both COX1 and COX2. There's some good reason to believe COX2 is safer.

1.)Source:/www.ncbi.nlm.nih.gov/pmc/articles/PMC4034022/
www.ncbi.nlm.nih.gov said...
5. Summary and Conclusions
In conclusion, to date, the available data in the literature on the effects of NSAIDS on IBD activity is inconclusive. It remains unclear whether NSAIDS and COX2 selective inhibitors indeed cause flares of IBD and whether COX2 inhibitors are safer than conventional NSAIDS. There is some evidence to suggest that short term usage of COX2 selective inhibitors is safe and beneficial in patients with IBD. Concomitant use of NSAIDS or COX2 inhibitors and steroids in patients with IBD warrants special consideration and careful monitoring due to the potentially increased cardiovascular and UGI toxicity, especially in older patients. Further research and controlled future clinical trials will help clear some of these topics.


2.)Source: /www.medpagetoday.com/gastroenterology/inflammatoryboweldisease/2616
medpagetoday.com said...
The researchers concluded that most patients with quiescent IBD can tolerate NSAIDs for a period of four weeks, but a significant minority will suffer a relapses within about a week.

The findings suggested, Dr. Bjarnason said, that "if a patient with IBD requires an NSAID for pain relief, then these drugs should not be withheld on the belief that they will cause worsening of disease symptoms."


The results also suggested, the researchers said, that selective inhibition of either of the COX enzymes is less likely to cause problems than blocking both of them.


I'd say if nothing else works then I'd cautiously try a NSAID for limited, and short term usage. If you have a problem that requires long term usage then find a better solution.
Moderator Ulcerative Colitis
John
, 39, UC Proctosigmoiditis
Rx: Remicade @5mgs/kg/6wks; daily 75mgs 6MP, 4.8g generic-Lialda, and rowasa

U.C. = Unimaginable Crapnado

Post Edited (iPoop) : 12/7/2017 2:13:01 PM (GMT-7)


notsosicklygirl
Forum Moderator


Date Joined Dec 2008
Total Posts : 15427
   Posted 12/8/2017 3:00 PM (GMT -7)   
The best pills for me are mini pills. if you have changing doses of hormones, that makes my migraines worse. When I was on cerazette I never got any migraines. I got an IUD, but it's been inconsistent. The pristiq was great, but probably similar to nortiptaline, and I didn't want to take it daily. If all else fails and you're open to it, i'd try pristiq. I tried maxalt and no luck. I used to have luck with zomig sometimes. It's really hard. There are SO many, and most don't seem to work. I never knew if they didn't work, or if it was just that I didn't take it early enough. I always doubt the aura is going to turn into a full fledged migraine, but it often does.
Co-moderator: Ulcerative Colitis
Currently: no meds. 6/15 Step One J-pouch Surgery Complete! 9/15 Step Two Complete! 11/15 Step 3 Complete!

Give a man a fish and he will eat for a day; teach a man to fish and he will eat for a lifetime; give a man religion and he will die praying for a fish.
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