You have to take the advice of the medical professionals you trust.
Is she going to an IBD center?
Has she received multiple opinions?
There are other options besides humira and Lialda, maybe she would do well on 6mp or imuran, or one of the other biologics. Rectal meds could help. Since she had c diff, I wonder if she would qualify for a fecal transplant, or something alternative along those lines? Has she been checked for Crohn's? Does she respond to antitbiocs?
I personally do not like steroids, they make me feel crazy, but everyone is different. As for as long-term physical health consequences, unfortunately, that is more similar amongst long-term users - bone loss, dental issues, eye problems, high blood pressure, suggestibility to bacterial and fungal infections, thrush, weight gain, skin issues, hormonal imbalances are common... If you use steroids long-term, you will eventually have side effects, and some may be permanent. I do not know how that would go for 5 days a month, but i'd imagine 5 days would turn into 10, then 15, then daily after some time. I was a fat, bloated insomniac with high blood pressure on prednisone. It made me depressed to look in the mirror. I hit a point where anything was better than having any of the drug in my body.
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Give a man a fish and he will eat for a day; teach a man to fish and he will eat for a lifetime; give a man religion and he will die praying for a fish